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Anti-respiratory virus traditional Chinese medicine composite and preparation method and application thereof

A technology of anti-respiratory tract and composition, applied in the direction of antiviral agents, drug combinations, respiratory diseases, etc.

Active Publication Date: 2011-11-09
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still few reports on the effect sites and effect components of the compound, and the pharmacological effects and mechanisms of common respiratory viruses, which is far from the actual needs of the majority of patients.

Method used

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  • Anti-respiratory virus traditional Chinese medicine composite and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] Example 1 Preparation of the volatile oil part of a Chinese medicine compound:

[0100] Take 40g of licorice, 60g of ephedra, 100g of bitter almond, 100g of pinellia, 200g of raw gypsum, 100g of fine tea, and 60g of schisandra to form a total of 660g. After crushing, put it in a 20000mL round-bottomed flask, add 10 times the amount of pure water, After shaking and mixing, soak for 30 minutes;

[0101] Connect the volatile oil extractor to the reflux condenser. Add water from the upper end of the condensing tube to fill the scale part of the volatile oil tester until it overflows into the flask. Put it in an electric heating mantle and heat it slowly to 110°C to boil, and keep boiling for 8 hours until the oil volume in the tester no longer increases, stop heating, let it stand for a while, open the lower piston of the tester, and slowly release the water until the upper end of the oil layer reaches 5mm above the 0 line on the scale. Leave it for more than 1 hour, and...

Embodiment 2

[0102] Embodiment 2 A kind of preparation method of Chinese medicine compound volatile oil, the steps are as follows:

[0103] Take 80g of licorice, 120g of ephedra, 200g of bitter almond, 200g of pinellia, 400g of raw gypsum, 200g of fine tea, and 120g of schisandra to form a total of 1320g. After crushing, put it in a 20,000mL round-bottomed flask, add 10 times the quality of medicinal materials in purified water, shake After shaking to mix, soak for 30min.

[0104] Connect the volatile oil extractor to the reflux condenser. Add water from the upper end of the condenser tube to fill the scale part of the volatile oil extractor until it overflows into the flask. Put it in an electric heating mantle and heat it slowly to 110°C boiling, and keep boiling for 8 hours until the oil volume in the extractor no longer increases, stop heating, let it stand for a while, open the lower piston of the extractor, and slowly release the water until the oil layer reaches the upper end 5mm ...

Embodiment 3

[0105] Embodiment 3 A kind of preparation method of ethyl acetate part of traditional Chinese medicine compound recipe, the steps are as follows:

[0106] Take 40g of licorice, 60g of ephedra, 100g of bitter almond, 100g of pinellia, 200g of raw gypsum, 100g of fine tea, and 60g of schisandra to form a total of 660g. After crushing, put it in a 20000mL round-bottomed flask, add 10 times the amount of pure water, After shaking and mixing, soak for 30min and connect the reflux condenser. Place in an electric heating mantle and heat slowly to 110°C to boil, and keep boiling slightly for 2 hours, stop heating, place the flask until the temperature is close to room temperature, filter and pour out the liquid medicine.

[0107] Then add 8 times the amount of pure water into the flask, shake and mix, soak for 30min, and connect the reflux condenser. Place in an electric heating mantle and heat slowly to 110°C to boil, and keep boiling slightly for 1 hour, stop heating, place the fla...

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Abstract

The invention discloses a compound Chinese traditional medicine anti-respiratory virus effective component and a preparation method. The effective component is a compound Chinese traditional medicine essential oil component extracted by a steam distillation method and an ethyl acetate component extracted by an extraction method by utilizing crude drug which is prepared by liquorice, ephedra, bitter almonds, pinellia, gypsum, tea bust and schisandra in parts by weight. The invention has the advantages of simple preparation process, good ruggedness and low cost, and simultaneously maximally improves the extraction ratio of effective constituents in the compound. In-vitro tests show that the compound Chinese traditional medicine essential oil component and the ethyl acetate component provided by the invention have stronger anti-influenza A virus effect; the ethyl acetate component has stronger anti-respiratory syncytial virus effect; and the essential oil component has anti-influenza B virus effect. The compound Chinese traditional medicine essential oil component and the ethyl acetate component of the invention can be used for preparing new Chinese traditional medicine for preventing upper respiratory tract-related virus infection, and provide a new choice for preparing anti-respiratory virus medicine by utilizing Chinese traditional medicine compound with traditional treatment advantages.

Description

technical field [0001] The invention relates to an anti-respiratory virus effective part of a traditional Chinese medicine compound and a preparation method thereof, as well as an application in preparation and treatment of an anti-respiratory virus, and belongs to the technical field of extraction and application of effective parts of a traditional Chinese medicine compound in the field of traditional Chinese medicine. Background technique [0002] Respiratory tract virus infection is a common clinical disease, which can occur in all age groups, with various clinical manifestations, among which severe cases are bronchiolitis and pneumonia, which can cause acute respiratory distress, heart failure, and even death. Respiratory viruses are easy to mutate, and some new diseases often occur, posing a threat to human life, so it has attracted extensive attention. [0003] In the course of fighting against diseases for more than 2,000 years, traditional Chinese medicine has summar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8888A61P31/12A61P11/00A61K33/06
Inventor 范欣生俞晶华唐于平周玲段金廒
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE