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Niclofolan-contained compound sustained-release animal parasiticide

A technology of slow-release anthelmintic and nichlorophene, which is applied in the field of broad-spectrum anti-parasitic veterinary drugs, can solve the problems of multiple infections and mixed infection of livestock and poultry parasites, and achieves convenient use, simple operation and good sustained-release effect Effect

Inactive Publication Date: 2010-03-10
WUWEI HONGNIU AGRI ANIMAL HUSBANDRY SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a veterinary compound slow-release anthelmintic containing nitrophenol to solve the problems of mixed infection and multiple infection of livestock and poultry parasites in existing animal husbandry

Method used

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  • Niclofolan-contained compound sustained-release animal parasiticide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1 "Nitrophen + Abamectin" formula

[0070] Preparation method: Weigh 50% (W / W) of nitrophenol, 5% (W / W) of abamectin and 20% (W / W) of hydroxypropyl methylcellulose and pass through 80 mesh sieves respectively, press etc. The amount is added and mixed, and the polyvinylpyrrolidone absolute ethanol solution is used as a binder 25% (W / W) to make tablets, each containing 125 mg of nitrophenol and 12.5 mg of abamectin.

[0071] Instructions Orally, swallow or crush the mixture once, the amount is 0.3mg per 1kg body weight of cattle and sheep (calculated as abamectin). Avoid light, airtight, and store in a cool place.

[0072] Case: The Animal Husbandry and Veterinary Station of Qingyuan Town, Wuwei City received 17 beef cattle raised by Mr. Liu in the township. He was diagnosed with itchy skin mite. Scraped dander from sick cows for microscopic examination, and it was diagnosed as yellow cattle acariosis. Compound nitrophenol tablets ("nitrophenol + abamectin" form...

Embodiment 2

[0073] Example 2 "nitrophenol + albendazole" formula

[0074] Preparation method: Weigh nitrophenol 10% (W / W), albendazole 20% (W / W) and hydroxypropyl methylcellulose 20% (W / W) and pass through 80 mesh sieve respectively, press etc. The amount is added and mixed, and the polyvinylpyrrolidone absolute ethanol solution is used as a binder 50% (W / W) to make tablets, each containing 25 mg of nitrophenol and 50 mg of albendazole.

[0075] Instructions for oral administration, swallow or crush the mixture once, the amount is 10-15mg per 1kg body weight of cattle and sheep (calculated as albendazole). Avoid light, airtight, and store in a cool place.

[0076] Case: A large sheep-raising family in Xiashuang Township, Wuwei City used the compound nitrophenol tablets ("nitrophenol + albendazole" formula type) developed by our factory to deworm sheep in autumn. 27 sheep were selected for clinical trials. Before the test, all had different degrees of parasitic infection symptoms, such a...

Embodiment 3

[0077] Example 3 "Nitrophen + Ivermectin" formula

[0078] Preparation method: Weigh 30% (W / W) of nitrophenol, 3% (W / W) of ivermectin and 40% (W / W) of hydroxypropyl methylcellulose and pass through 80 mesh sieves respectively, and press etc. The amount is added and mixed, and the polyvinylpyrrolidone absolute ethanol solution is used as a binder 27% (W / W) to make tablets, and each tablet contains 75 mg of nitrophenol and 7.5 mg of ivermectin.

[0079] Instructions Orally, swallow or crush the mixture once, the amount is 0.3mg per 1kg body weight of cattle and sheep (calculated as ivermectin). Avoid light, airtight, and store in a cool place.

[0080] Case: A large sheep-raising family in Wuwei City used the compound nitrophenol tablets ("nitrophenol + ivermectin" formula type) developed by our factory to deworm sheep in autumn. The 38 selected sheep were tested. Symptoms of different degrees of parasitic infection, sneezing, hitting the wall, shaking head, biting from time t...

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Abstract

The invention discloses a niclofolan-contained compound sustained-release animal parasiticide, aiming at solving the problems of parasitic mixed infection or multiple infection of the livestock and the poultryin the livestock and poultry cultivation. The niclofolan-contained compound sustained-release animal parasiticide comprises the following raw materials by weight percent: 10-50 percent of niclofolan, 3-20 percent of parasite repellent, 10-40 percent of sustained-release matrix material, and the balance of adhesive. The parasite repellent is one of the ivermectin, the avermectins and the albendazole; the sustained-release matrix material is the hydroxypropyl methyl cellulose; and the adhesive is polyvinylpyrrolidone. The niclofolan-contained compound sustained-release animal parasiticide has broad spectrum and good sustained-release effect, can repel different age groups of various parasite larvae parasitized on the livestock and the poultry by over 97.5 percent, is convenient to use and saves the animal treatment cost. The niclofolan-contained compound sustained-release animal parasiticide can prevent the livestock and the poultry against spring weakness death and weight losscaused by the parasites, thereby being an ideal medicament of preventing the livestock and the poultry like the cattle and the sheep against the parasites.

Description

technical field [0001] The invention belongs to a broad-spectrum anti-parasitic veterinary drug used in veterinary clinics for treating and preventing internal and external parasitic diseases of livestock and poultry. Background technique [0002] Livestock and poultry parasitic diseases are common diseases that plague the development of livestock and poultry. There are many types of pathogens and a wide range of distribution. They can cause various chronic wasting diseases and infectious diseases of livestock and poultry. The quality and quantity of livestock and poultry products are reduced, and the economic benefits of animal husbandry are seriously damaged. Therefore, using effective antiparasitic drugs to regularly deworm and kill insects is an important link in the comprehensive control of livestock and poultry parasites, and has important practical significance for the development of animal husbandry and breeding. [0003] Common parasitic diseases of livestock and p...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/06A61K31/4184A61P33/00A61P33/14
Inventor 樊建华
Owner WUWEI HONGNIU AGRI ANIMAL HUSBANDRY SCI & TECH
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