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Fast sieving method for dihydropyridine blood-pressure lowering compound mixed in Chinese medicinal herb blood-pressure lowering product
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A technology for dihydropyridine and compound is applied in the detection field of dihydropyridine antihypertensive compounds, and can solve the problems of inability to detect nifedipine, nitrendipine and nimodipine, inability to obtain experimental results, inability to judge detection results, and the like, Achieve the effect of short detection time, high promotion and application value, and improved sensitivity
Active Publication Date: 2011-03-16
广东省药品检验所
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Abstract
Description
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Problems solved by technology
[0007] The identification method of nifedipine and nitrendipine in the Pharmacopoeia uses acetone as the solvent, and sodium hydroxide and potassium hydroxide are easy to precipitate in the acetone solution. The experiment is carried out according to the identification method recorded in the Pharmacopoeia, and the experimental results described can not be obtained.
And the differential method of nimodipine in Pharmacopoeia selects ethanol as solvent, well-known, sodium hydroxide and potassium hydroxide are soluble in ethanol, but nifedipine, nitrendipine and nimodipine are almost insoluble in ethanol, therefore, simple Solvent replacement (ethanol instead of acetone) also failed to detect nifedipine, nitrendipine, and nimodipine
On the other hand, even if the purity of the medicine is as high as more than 90% (the purity used by the identification method recorded in the Pharmacopoeia), the color presented by the reaction in 20% sodium hydroxide-water solution is also very light, not to mention the The content of nifedipine, nitrendipine and nimodipine is low (less than 10%), and its reaction in 20% sodium hydroxide-water solution is less sensitive, and the color change is less obvious, and the extraction of Chinese herbal antihypertensive products The liquid generally has a darker color (brownish yellow), and the color change of the reaction is often covered, so it is impossible to judge the test result
Furthermore, 20% sodium hydroxide-water solution is a high-concentration strong alkaline solution, which is highly corrosive and extremely inconvenient to store and use
Therefore, the identification method recorded in the Pharmacopoeia is not suitable for detecting whether nifedipine, nitrendipine and nimodipine are adulterated in Chinese herbal antihypertensive products
Method used
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Effect test
Embodiment 1
[0092] The composition of the test kit is:
[0093] Reagent A: Acetone-ethanol solution with a volume ratio of 5:1;
[0094] Reagent B: potassium hydroxide-ethanol solution with a mass concentration of 2%;
[0095] The kit also includes 10 5ml sample bottles with stoppers, 10 filters and 10 graduated syringes.
[0096] Take 1 Qingnao Jiangya tablet, break it, add reagent A equivalent to 5 times the mass of Qingnao Jiangya tablet, shake to dissolve, filter, the filtrate is light brown, take 1ml of the filtrate, add 5 drops of reagent B , Shake well, the solution has no color change, and the result is consistent with reality.
Embodiment 2
[0098] The composition of the test kit is:
[0099] Reagent A: Acetone-ethanol solution with a volume ratio of 5:1;
[0100] Reagent B: potassium hydroxide-ethanol solution with a mass concentration of 3%;
[0101] The kit also includes 20 5ml vials with stoppers, 20 filters and 20 graduated syringes.
[0102] Take 1 compound Danshen tablet, break it, add Reagent A equivalent to 6 times the mass of the compound Danshen tablet, shake to dissolve, filter, the filtrate is light brownish yellow, take 1ml of the filtrate, drop 3 drops of Reagent B, shake well, There is no color change in the solution, and the result is consistent with reality.
Embodiment 3
[0104] The composition of the test kit is:
[0105] Reagent A: Acetone-ethanol solution with a volume ratio of 5:1;
[0106] Reagent B: potassium hydroxide-ethanol solution with a mass concentration of 2%;
[0107] The kit also includes a 5ml sample bottle with stopper, a filter head and a graduated syringe.
[0108] Take 1 capsule of Naoliqing capsule, mix 1mg of nifedipine, add reagent A equivalent to 7 times the total mass of Naoliqing capsule and nifedipine, shake to dissolve, filter; take 1ml of filtrate, drop Add 4 drops of Reagent B and shake well. The solution turns from light yellow to reddish brown. The result is consistent with the actual situation.
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Abstract
The invention relates to a fast sieving method for a dihydropyridine blood-pressure lowering compound mixed in a Chinese medicinal herb blood-pressure lowering product. The fast sieving method comprises the following steps of: (1) sampling, crushing, adding acetone-ethanol solution with volume ratio to a sample of equal to 5 : 1 and mass of 5 times to 10 times of the sample, shaking for dissolution, filtering and keeping filtering solution; (2) taking out 1ml of the filtering solution obtained from step (1), adding with 3 drops to 5 drops of potassium hydroxide-ethanol solution with mass concentration of equal to 2 percent to 3 percent, shaking evening and observing the change of color; in the case that the solution is changed into reddish-brown, which shows the dihydropyridine blood-pressure reducing compound is doped in the sample; and the dihydropyridine blood-pressure reducing compound is one or more than two of nifedipine, nitrendipine and nimodipine. The invention also disclosesa special kit for applying the method and the kit comprises the acetone-ethanol solution with volume ratio of 5 to 1 and the potassium hydroxide-ethanol solution with mass concentration of equal to 2percent to 3 percent. The sieving method is characterized by fastness, low cost, simple operation and the like.
Description
Technical field [0001] The invention relates to the detection of non-biological materials using chemical indicators, and in particular to a detection method of dihydropyridine antihypertensive compounds. Background technique [0002] Antihypertensive Western medicines can be roughly divided into five categories according to their pharmacological differences, diuretics, β-receptor blockers, calcium antagonists (CCB), angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor antagonists (ARB). Long-term overdose of antihypertensive western medicine will bring serious side effects, such as numbness of the lips, headache, gastrointestinal bleeding, decreased liver function or even loss, and induce or worsen diabetes. [0003] Under the lure of huge economic benefits, some unscrupulous manufacturers took advantage of consumers' eagerness for treatment and the misunderstanding of the non-toxic side effects of traditional Chinese medicines, and mixed them with Chinese h...
Claims
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Application Information
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