Propofol self-micro-emulsifying composition and preparation method thereof
A technology of self-microemulsification and propofol, which is applied to the active ingredients of hydroxyl compounds, drug combinations, drug delivery, etc., can solve the problems of injection pain and low oral bioavailability, to promote absorption, improve oral bioavailability, Good patient compliance
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[0025] Example 1
[0026] Proportion: Propofol 10g
[0027] Polyoxyethylene hydrogenated castor oil 40 60g
[0028] Divinyl glycol monoethyl ether 20g
[0029] Isopropyl myristate 10g
[0030] Butyl hydroxyanisole 0.02%
[0031] Preparation method: Weigh an appropriate amount of propofol, add the prescribed amount of oil phase, emulsifier, co-emulsifier and antioxidant, stir and mix to obtain isopropyl at room temperature, protected from light and nitrogen. Phenol self-microemulsifying composition.
Example Embodiment
[0032] Example 2
[0033] Proportion: Propofol 10g
[0034] Polyoxyethylene hydrogenated castor oil 40 56g
[0035] Isopropyl alcohol 19g
[0036] Isopropyl myristate 15g
[0037] Tert-butyl hydroquinone 0.02%
[0038] Preparation method: Weigh an appropriate amount of propofol, add the prescribed amount of oil phase, emulsifier, co-emulsifier and antioxidant, stir and mix to obtain isopropyl at room temperature, protected from light and nitrogen. Phenol self-microemulsifying composition. The prepared self-emulsifying microemulsion composition is prepared into the storage layer of the transdermal patch, which is sequentially compounded with the backing layer and the pressure-sensitive layer on one side, and then compounded with the controlled release layer and the protective layer on the other side. The transdermal patch containing self-emulsifying microemulsion is obtained.
Example Embodiment
[0039] Example 3
[0040] Proportion: Propofol 10g
[0041] Polyoxyethylene castor oil 35 45g
[0042] Isopropyl alcohol 30g
[0043] Ethyl oleate / corn oil (2∶1) 15g
[0044] Butyl hydroxyanisole 0.02%
[0045] Preparation method: Weigh an appropriate amount of propofol, add the prescribed amount of oil phase, emulsifier, co-emulsifier and antioxidant, stir and mix to obtain isopropyl at room temperature, protected from light and nitrogen. Phenol self-microemulsifying composition.
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