Methods of treatment using intravenous formulations comprising temozolomide

A technology for temozolomide and preparations, which is applied in the treatment field of using preparations for intravenous injection containing temozolomide, can solve the problems of reducing the bioavailability of drugs and the like
CN101678002AInactive Publication Date: 2010-03-24MERCK & CO INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
MERCK & CO INC
Publication Date
2010-03-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention relates to methods and drug products for treating proliferative disorders using intravenous formulations comprising temozolomide over a specific infusion time. These methods and drug products are particularly well-suited for patients who cannot swallow oral formulations. These methods and drug products also afford an added convenience to patients who are already receiving other therapeutic treatments.
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Description

technical field

[0001] The present invention relates to methods and medicaments for the treatment of proliferative disorders using intravenous formulations containing temozolomide over specific infusion times. These methods and medicaments are especially useful for patients who cannot swallow oral formulations. These methods and medicaments also provide additional convenience for patients already undergoing other therapeutic treatments. Background technique

[0002] Brain tumors account for approximately 2% of all malignancies. Stupp et al., J. Clin. Onc., 20(5):1375-1382 (2002). In the United States, more than 17,000 cases are diagnosed each year and there are about 13,000 related deaths. The standard regimen for the treatment of malignant gliomas involves cytoreduction by surgical resection when feasible, followed by radiation therapy (RT), with or without adjuvant chemotherapy. The paper by Stupp et al. mentioned above.

[0003] Temozolomide or TMZ (supplied by Scher...

Claims

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