Application of potassium chloride (KCl) in pharmacy

An anti-oxidative stress, drug technology, applied in the field of medicine, can solve problems such as no KCl neuron damage

Inactive Publication Date: 2010-04-21
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, KCl protection of neurons from MPP has not been seen in the prior art + Reports on the role of injury

Method used

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  • Application of potassium chloride (KCl) in pharmacy
  • Application of potassium chloride (KCl) in pharmacy
  • Application of potassium chloride (KCl) in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: Dissolve 250 mg of KCl (KCl from Tianjin No. 3 Chemical Reagent Factory), dissolve it in 1000 ml of water to make a 0.25% concentration aqueous solution, heat and dissolve, mix well, put it into a medicine bottle, seal it, and sterilize it to make a product.

Embodiment 2

[0019] Example 2: 125 mg of KCl (KCl was purchased from Tianjin No. 3 Chemical Reagent Factory) was dissolved in 1000 ml of water to prepare an aqueous solution of 0.125% concentration by heating and dissolving. After mixing, it was sealed in a medicine bottle and sterilized to make a product.

Embodiment 3

[0020] Embodiment 3: KCl (KCl was purchased from Tianjin No. 3 Chemical Reagent Factory) 2500mg, dissolved in 1000ml water to make an aqueous solution, heated to dissolve, after mixing evenly, packaged into the injection of 5mg / 2ml / branch concentration and sealed in a medicine bottle , sterilized products.

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PUM

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Abstract

The invention relates to a new medical use of KCl, application of the KCl as nerve cell growth promoter, PC12 cell growth promoter, antioxidant stress damage agent and PC12 cell parkinson toxic-free damage agent, and application of the KCl in preparing medicament for treating Parkinson disease. By adopting a methyl thazolyl tetrazolium (MTT) method, the KCl is found to have the effects of promoting the growth of adrenal gland chromaffin tumor cell (PC12 cell), promoting the activity of the nerve cell multiplication and inhibiting the damage of the nerve cell caused by the Parkinson toxic substance MPP+(1-Methy1-4-Phenylpyridinium ion). The western blotting method shows that the KCl can induce the expression level of thioredoxin in the PC12 cell. Therefore, the KCl for protecting the nerve cells against the toxicity MPP+ is related to the expression of the thioredoxin.

Description

Technical field: [0001] The invention relates to the technical field of medicine, specifically to the new medical use of KCl, and to KCl as an agent for promoting nerve cell growth, an agent for promoting PC12 cell growth, an agent for resisting oxidative stress damage, and an agent for preventing PC12 cells from being damaged by Parkinson's virus. and the application of KCl in the preparation of medicines for the treatment of Parkinson's disease. Background technique: [0002] KCl can depolarize the cell membrane, excite cells, change the permeability of ion channels, and regulate calcium ion channels on the plasma membrane and calcium reservoir membrane, thereby causing an increase in intracellular free calcium ions, so it is usually used to establish tissue ischemia. Model of the resulting increase in intracellular calcium ion concentration (William J. Moody and Martha M. Bosma. Ion Channel Development, Spontaneous Activity, and Activity-Dependent Development in Nerve and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61P25/00A61P25/16A61P39/00A61P43/00
Inventor 白洁李彦辉
Owner KUNMING UNIV OF SCI & TECH
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