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Ecabet sodium granules and preparation method thereof

A technology of ecabet sodium and granules, which is applied in the field of ecabet sodium granules and its preparation, and can solve the problems of high cost and cumbersome preparation methods, etc.

Active Publication Date: 2013-11-20
JIANGSU YABANG QIANGSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the preparation method of this gel preparation is more loaded down with trivial details, and cost is higher

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Preparation prescription of the present invention is made up of following components by weight:

[0016] Ecabet Sodium 100g

[0017] Glyceryl monostearate 40g

[0018] Mannitol 4g

[0019] Aspartame 4g

[0020] Orange essence 1g

[0021] Peppermint essence 1g

[0022] 10% PVP K30 Proper amount of ethanol solution

[0023] A total of 100 bags were made

[0024] Preparation process 1:

[0025] (1) passing the ecabet sodium raw material through a 100-mesh sieve for subsequent use;

[0026] (2) Glyceryl monostearate was weighed according to the prescription, after melting at 70°C, it was added to the ecabet sodium raw material, stirred into large particles, and passed through a 40-mesh sieve;

[0027] (3) Weigh aspartame, mannitol, orange flavor, peppermint flavor according to the prescription and mix them evenly with the granules obtained in (2), and use an appropriate amount of 10% PVP k30 Soft material made from ethanol solution, granulated at 20 mesh, dri...

Embodiment 2

[0035] Preparation prescription of the present invention is made up of following components by weight:

[0036] Ecabet Sodium 100g

[0037] Stearic acid 50g

[0038] Mannitol 4g

[0039] Aspartame 4g

[0040] Orange essence 1g

[0041] Peppermint essence 1g

[0042] 10% PVP K30 Proper amount of ethanol solution

[0043] A total of 100 bags were made

[0044] Preparation process 1:

[0045] (1) passing the ecabet sodium raw material through a 100-mesh sieve for subsequent use;

[0046] (2) Take stearic acid by prescription, after melting at 70°C, add it to the ecabet sodium raw material, stir into large particles, and pass through a 40-mesh sieve;

[0047] (3) Weigh aspartame, mannitol, orange flavor, peppermint flavor according to the prescription and mix them evenly with the granules obtained in (2), and use an appropriate amount of 10% PVP k30 Soft materials made from ethanol solution, granulated at 20 mesh, dried at 60°C, granulated at 20 mesh to make ecabet ...

Embodiment 3

[0055] Preparation prescription of the present invention is made up of following components by weight:

[0056] Ecabet Sodium 100g

[0057] Macrogol 6000 40g

[0058] Mannitol 4g

[0059] Aspartame 4g

[0060] Orange essence 1g

[0061] Peppermint essence 1g

[0062] 10% PVP K30 Proper amount of ethanol solution

[0063] A total of 100 bags were made

[0064] Preparation process 1:

[0065] (1) passing the ecabet sodium raw material through a 100-mesh sieve for subsequent use;

[0066] (2) Weigh polyethylene glycol 6000 according to the prescription, melt it at 70°C, add it to the raw material of ecabet sodium, stir it into large particles, and pass through a 40-mesh sieve;

[0067] (3) Weigh aspartame, mannitol, orange flavor, peppermint flavor according to the prescription and mix them evenly with the granules obtained in (2), and use an appropriate amount of 10% PVP k30 Soft material made from ethanol solution, granulated at 20 mesh, dried at 60°C, granulated a...

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PUM

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Abstract

The invention relates to Ecabet sodium granules and a preparation method thereof. The preparation method provided by the invention can obviously improve the taste of the Ecabet sodium granules and enhances the obedience of patients.

Description

technical field [0001] The invention relates to ecabet sodium granules and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Ecabet sodium is a protective agent for gastric mucosa, which forms a barrier protective layer by combining with gastric mucosa to protect gastric mucosa from digestion and corrosion of gastric juice; it can also combine with pepsinogen and pepsin protein to inhibit Enzyme activity can increase endogenous prostaglandins and improve gastric mucosal defense factors (such as increasing mucus volume, improving blood flow, increasing alkaline secretion), etc. [0003] Ecabet sodium was first developed by Japan Tanabe Company, and it was listed in Japan in 1993 as granules with a specification of 1.5g: 1g. The raw material of ecabet sodium is tasteless at the beginning, but it will gradually produce a strong bitter taste. If the common preparation process is adopted, when the oral dose is lar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/255A61P1/04
Inventor 陈再新葛育红赵晓红毛白杨谢瑞丽孙海棠
Owner JIANGSU YABANG QIANGSHENG PHARMA