Anti-cold medical composition and preparation method thereof

Abstract

The invention relates to an anti-cold medical composition consisting of active components of loratadine, acetaminophen, pseudoephedrine sulfate and pharmaceutically acceptable auxiliary materials. The medical composition is a double-layered sustained-release tablet with a quick release outer layer coating a sustained-release core. The quick release outer layer comprises loratadine and pseudoephedrine sulfate while the sustained-release part comprises acetaminophen and pseudoephedrine sulfate. The double-layered composition is used for relieving sneeze, rhinorrhea, nasal obstruction, laryngeal discomfort, weakness, fever, sore muscle, headache and the like which are caused by cold or seasonal allergic rhinitis.

Description

technical field [0001] The invention relates to an anti-cold medicine, in particular to a slow-release tablet with loratadine, acetaminophen and pseudoephedrine sulfate as active ingredients and a preparation method thereof. Background technique [0002] There are many varieties of anti-cold drugs on the market, but there is no specific therapeutic drug yet. Common medicines usually all relieve corresponding cold symptoms, and generally can be divided into the following categories: 1. Antiallergic drugs: as diphenhydramine, terfenadine, chlorpheniramine maleate, loratadine (not Cause drowsiness), etc., for the relief of nasal congestion, runny nose, sneezing and other symptoms. 2. Drugs to relieve nasal congestion: such as pseudoephedrine, etc., used to relieve nasal symptoms such as nasal congestion and nasal congestion. 3. Antipyretic and analgesic drugs: such as aspirin, paracetamol, ibuprofen, etc., used to reduce fever, relieve headache and muscle aches and other symp...

AI Technical Summary

Problems solved by technology

The technical schemes of the above two patent applications are combined or directly mixed to prepare sustained-release capsules, but it is not very scientific, because loratadine does not need to be prepared into sustained-release capsules to effectively relieve clinical symptoms

Especially in the Chinese patent application 200610140549.6, although it is stated that the sustained-release capsule includes the loratadine immediate-release part, but from the preparation method described in its examples, it is not seen that it has a special loratadine fast-release part. The preparation process of the release system is described, but it is simply mixed with other ingredients and prepared in the sustained release capsule