Anti-cold medical composition and preparation method thereof

A technology of composition and cold, which is applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems that are not very scientific, and the description of the preparation process of the loratadine immediate-release system has not been seen, and achieve Mild and long-lasting antipyretic effect, less side effects and quick curative effect

Inactive Publication Date: 2010-06-09
SHENZHEN NEPTUNUS PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The technical schemes of the above two patent applications are combined or directly mixed to prepare sustained-release capsules, but it is not very scientific, because loratadine does not need to be prepared into sustained-release capsules to effectively relieve clinical symptoms
Especially in the Chinese patent application 200610140549.6, although it is stated that the sustained-release capsule includes the loratadine immediate-release part, but from the preparation method described in its examples, it is not seen that it has a special loratadine fast-release part. The preparation process of the release system is described, but it is simply mixed with other ingredients and prepared in the sustained release capsule

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1, the preparation of a kind of anti-cold medicinal composition

[0016] Sustained-release tablet core components:

[0017] components

mg / tablet

Acetaminophen

400mg

pseudoephedrine sulfate

40mg

Glyceryl behenate

60mg

Polyvinylpyrrolidone K30 (PVP K30)

20mg

Magnesium stearate

1mg

[0018] Immediate Release Cover Components:

[0019] components

mg / tablet

Loratadine

2.5mg

Acetaminophen

20mg

microcrystalline cellulose

40mg

Polyvinylpyrrolidone K30 (PVP K30)

5mg

Crospovidone

30mg

[0020] Preparation:

[0021] 1), acetaminophen, pseudoephedrine sulfate, and PVP K30 were pulverized and passed through a 100-mesh sieve before use;

[0022] 2), preparation of mixed powder:

[0023] Take component amounts of acetaminophen, pseudoephedrine sulfate, glyceryl behenate, and polyvinylpyrrolidone K30 and mix them through a ...

Embodiment 2

[0027] Embodiment 2, the preparation of a kind of anti-cold medicinal composition

[0028] Sustained-release tablet core components:

[0029] components

[0030] Immediate Release Cover Components:

[0031] components

[0032] The preparation method is the same as in Example 1.

Embodiment 3

[0033] Embodiment 3, the preparation of a kind of anti-cold medicinal composition

[0034] Sustained-release tablet core components:

[0035] components

[0036] Immediate Release Cover Components:

[0037] components

[0038] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention relates to an anti-cold medical composition consisting of active components of loratadine, acetaminophen, pseudoephedrine sulfate and pharmaceutically acceptable auxiliary materials. The medical composition is a double-layered sustained-release tablet with a quick release outer layer coating a sustained-release core. The quick release outer layer comprises loratadine and pseudoephedrine sulfate while the sustained-release part comprises acetaminophen and pseudoephedrine sulfate. The double-layered composition is used for relieving sneeze, rhinorrhea, nasal obstruction, laryngeal discomfort, weakness, fever, sore muscle, headache and the like which are caused by cold or seasonal allergic rhinitis.

Description

technical field [0001] The invention relates to an anti-cold medicine, in particular to a slow-release tablet with loratadine, acetaminophen and pseudoephedrine sulfate as active ingredients and a preparation method thereof. Background technique [0002] There are many varieties of anti-cold drugs on the market, but there is no specific therapeutic drug yet. Common medicines usually all relieve corresponding cold symptoms, and generally can be divided into the following categories: 1. Antiallergic drugs: as diphenhydramine, terfenadine, chlorpheniramine maleate, loratadine (not Cause drowsiness), etc., for the relief of nasal congestion, runny nose, sneezing and other symptoms. 2. Drugs to relieve nasal congestion: such as pseudoephedrine, etc., used to relieve nasal symptoms such as nasal congestion and nasal congestion. 3. Antipyretic and analgesic drugs: such as aspirin, paracetamol, ibuprofen, etc., used to reduce fever, relieve headache and muscle aches and other symp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4545A61K31/167A61K31/137A61K9/24A61P31/16A61P29/00
Inventor 王兵黄传贵陈红朱丹叶勤冯汉林于琳
Owner SHENZHEN NEPTUNUS PHARM CO LTD
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