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Application of prince feather-containing composition in preparation of medicaments of treating blood vessels of brain and diseases related to blood vessels of brain

A technology for preparing medicines and compositions, applied in the field of application of compositions in the preparation of medicines for treating cerebrovascular and related diseases

Active Publication Date: 2012-05-30
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It is mainly used for coronary heart disease angina pectoris with heart-blood stagnation syndrome, symptoms include chest tightness, chest pain, immobility, palpitations, dark purple lips and tongue, thready pulse and other coronary heart disease angina pectoris with the above syndromes. Report on Clinical Pharmacological Research of the Composition on Prevention and Treatment of Cerebrovascular and Related Diseases

Method used

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  • Application of prince feather-containing composition in preparation of medicaments of treating blood vessels of brain and diseases related to blood vessels of brain
  • Application of prince feather-containing composition in preparation of medicaments of treating blood vessels of brain and diseases related to blood vessels of brain
  • Application of prince feather-containing composition in preparation of medicaments of treating blood vessels of brain and diseases related to blood vessels of brain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0136] 5 parts of oriental grass, 4 parts of hawthorn leaves, 3 parts of Panax notoginseng and 3 parts of Chuanxiong (the parts are parts by weight, the following examples are parts by weight)

[0137] The oriental grass, hawthorn leaves, and Panax notoginseng were boiled 3 times with 10 times the amount of water, each time for 1 hour, filtered, the filtrate was combined, concentrated under reduced pressure to a relative density of 1.10, and ethanol was added to make the alcohol content reach 65%, stir well, Let stand for 12 hours, filter with suction, recover ethanol under reduced pressure from the filtrate and concentrate it to a relative density of 1.07, add an appropriate amount of water for dilution, a macroporous adsorption resin column with an upper diameter-height ratio of 1:10, and an adsorption flow rate of 2BV h -1 , discard the permeate, wash with 1BV water, flow rate 2BV h -1 , discarded the water washing solution, followed by elution with 3BV 70% ethanol, the flo...

Embodiment 2

[0140] The Chuanxiong extract obtained in Example 1 was added to the extract mixture of oriental oriental, hawthorn leaves and Panax notoginseng, and then an appropriate amount of soybean oil containing 2% beeswax was added, and mixed well for subsequent use; with gelatin: glycerin: distilled water: preservative (mud) Gold methyl ester)=1:0.4:1:0.002 to prepare capsule material, and press to obtain soft capsule.

Embodiment 3

[0142] 6 parts of oriental grass, 5 parts of hawthorn leaves, 4 parts of Panax notoginseng and 3 parts of Chuanxiong

[0143] Add 10 times the amount of water to decoct oriental oriental and hawthorn leaves for 3 times, 1 hour each time, filter, combine the filtrates, concentrate under reduced pressure to a relative density of 1.10, add ethanol to make the alcohol content reach 65%, stir well, and let stand for 12 hours, suction filtration, the filtrate was decompressed to recover ethanol and concentrated to a relative density of 1.07, diluted with an appropriate amount of water, a macroporous adsorption resin column with a diameter-height ratio of 1:10, and an adsorption flow rate of 2BV h-1 , discard the permeate, wash with 1BV water, flow rate 2BV h -1 , discarded the water washing solution, followed by elution with 3BV 70% ethanol, the flow rate was 2BV h -1 , collect the eluent, reclaim ethanol, concentrate into thick paste, the residue is spray-dried, pulverized into fin...

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PUM

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Abstract

The invention discloses application of a prince feather-containing composition in the preparation of medicaments of treating blood vessels of brain and diseases related to blood vessels of brain, wherein the diseases related to blood vessels of brain comprise stroke, apoplectic sequelae, ischaemia, reperfusion injury, thrombus, vasoconstriction, emphraxis, and alzheimers disease, and also comprise dizziness caused by a variety of reasons; and the prince feather-containing composition is formed by extracts obtained by mixing Chinese medicinal materials of prince feather, hawthorn leaves, pseudo-ginseng and Chuanxiong rhizome and then extracting the mixture or extracting the Chinese medicinal materials respectively and then mixing the extracts. The invention provides the novel medical application of the prince feather-containing composition and also provides a novel medicinal selection for patients.

Description

technical field [0001] The present invention relates to the application of the composition, in particular to the application of the composition containing oriental orientalis in the preparation of medicine for treating cerebrovascular and related diseases. technical background [0002] Cerebrovascular disease is a common and frequently-occurring disease that endangers human life and health. Leading cause of death and disability in middle-aged people. The incidence of cerebrovascular disease is on the rise due to the continuous increase of the elderly population and the improvement of living standards. Globally, it kills 4.6 million people each year, mostly in people over the age of 65. my country is also an area with a high incidence of stroke mortality. It is estimated that 6 million residents are currently suffering from cerebrovascular disease, with 1.3 million new cerebrovascular diseases and nearly 1 million deaths each year. About 3 / 4 of the survivors are left with h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/734A61K36/704A61K9/48A61P9/10A61P9/02
Inventor 窦啟玲
Owner GUIZHOU YIBAI PHARMA CO LTD
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