Resolution method of R-(+)-1-(1-naphthyl) ethylamine

Abstract

The invention discloses a resolution method of R-(+)-1-(1-naphthyl) ethylamine, comprising the following steps of: reacting racemate 1-(1-naphthyl) ethylamine with the D-(-)-tartaric acid at room temperature or under a heating condition by using D-(-)-tartaric acid as a chiral resolving agent and a solution of alcohol and water as a solvent so as to generate enantiomer salt; then separating R-(+)-1-(1-naphthyl) ethylamine.D-(-)-tartrate out according to the different solubility of the enantiomer salt in the R-(+)-1-(1-naphthyl) ethylamine; then obtaining the R-(+)-1-(1-naphthyl) ethylamine through alkalization and dissociation, wherein an e.e. value can be achieved more than 95 percent, yield coefficient can be achieved by 30 percent, and a resolved mother solution can be converted into the racemate 1-(1-naphthyl) ethylamine through racemization and be resolved again. The resolution method has low cost and easy obtaining of raw materials, easy and convenient process operation and low cost; and in addition, the resolved mother solution can be resolved again through the racemization.

Description

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