Resolution method of R-(+)-1-(1-naphthyl) ethylamine

Abstract

The invention discloses a resolution method of R-(+)-1-(1-naphthyl) ethylamine, comprising the following steps of: reacting racemate 1-(1-naphthyl) ethylamine with the D-(-)-tartaric acid at room temperature or under a heating condition by using D-(-)-tartaric acid as a chiral resolving agent and a solution of alcohol and water as a solvent so as to generate enantiomer salt; then separating R-(+)-1-(1-naphthyl) ethylamine.D-(-)-tartrate out according to the different solubility of the enantiomer salt in the R-(+)-1-(1-naphthyl) ethylamine; then obtaining the R-(+)-1-(1-naphthyl) ethylamine through alkalization and dissociation, wherein an e.e. value can be achieved more than 95 percent, yield coefficient can be achieved by 30 percent, and a resolved mother solution can be converted into the racemate 1-(1-naphthyl) ethylamine through racemization and be resolved again. The resolution method has low cost and easy obtaining of raw materials, easy and convenient process operation and low cost; and in addition, the resolved mother solution can be resolved again through the racemization.

Description

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AI Technical Summary

Benefits of technology

This patented technology allows cyclodestructing different types of chemicals called l-(Naphthaflurophenylacetanilide). It has several advantages over existing methods such as complicated operation with high costs due to expensive starting materials used during production. Additionally it offers better efficiency than current techniques like separation by crystallizing them from their crude formulation.

Problems solved by technology

The technical problem addressed in this patented report relates to improving optically purity for certain compounds like caffeine or quaternary ammonium salts through chemical methods involving various reagents and solvents.