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Preparation and application of pharmaceutic preparation of 11-carbonyl-betal- acetyl mastic acid and derivatives thereof extracted from frankincense

The technology of a pharmaceutical preparation and boswellic acid, which can be used in drug combinations, non-central analgesics, and medical preparations containing active ingredients, etc.

Inactive Publication Date: 2010-07-14
凌沛学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

None of the above-mentioned patents has a description of the use of pharmaceutical preparations made from 11-carbonyl-β-acetylboswellic acid for rheumatoid arthritis

Method used

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  • Preparation and application of pharmaceutic preparation of 11-carbonyl-betal- acetyl mastic acid and derivatives thereof extracted from frankincense
  • Preparation and application of pharmaceutic preparation of 11-carbonyl-betal- acetyl mastic acid and derivatives thereof extracted from frankincense
  • Preparation and application of pharmaceutic preparation of 11-carbonyl-betal- acetyl mastic acid and derivatives thereof extracted from frankincense

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] 1. Extraction, separation and purification of 11-carbonyl-β-acetylboswellic acid

[0072]Take 1.5 kg of frankincense medicinal material, crush it into coarse particles, reflux extraction with 95% ethanol for 1.5 hours, filter, recover ethanol from the filtrate, and obtain 1.02 kg of alcohol extract, add 2.5% NaOH solution to slightly heat to dissolve, and stir for 4 hours , extracted 3 times with ethyl acetate, dilute the lye with water, adjust the pH value to 3-4 with 5% hydrochloric acid solution 2.5kg, filter with suction, wash the precipitate with water until neutral, vacuum dry (60°C), and pulverize to obtain frankincense Crude extract (containing 10% of 11-carbonyl-β-acetylboswellic acid) 0.31kg; add 1000ml of acetic anhydride, 60ml of pyridine, stir in ice bath for 8h, filter with suction, wash the precipitate with petroleum ether 3 times, filter with suction, and dry the precipitate (60°C), add 5000ml of acetone, 240g of anhydrous potassium carbonate, heat and r...

Embodiment 2

[0083] 1. Extraction, separation and purification of 11-carbonyl-β-acetylboswellic acid

[0084] Take 1.5 kg of frankincense medicinal material, crush it into coarse particles, extract it with 90% ethanol under reflux for 2 hours, filter, recover ethanol from the filtrate, and obtain 0.95 kg of alcohol extract, add 2.5% NaOH solution 2.4 kg to slightly heat to dissolve, and stir for 4 hours , extracted 4 times with ethyl acetate, dilute the lye with water, adjust the pH value to 3-4 with 2.2kg of 5% hydrochloric acid solution, filter with suction, wash the precipitate with water until neutral, dry in vacuum (60°C), and pulverize to obtain frankincense Crude extract (containing 10% of 11-carbonyl-β-acetylboswellic acid) 0.28kg; add 900ml of acetic anhydride, 80ml of pyridine, stir in ice bath for 8h, filter with suction, wash the precipitate with petroleum ether for 3 times, filter with suction, and dry the precipitate (60°C), add acetone 6000ml, anhydrous potassium carbonate 2...

Embodiment 3

[0093] 1. Extraction, separation and purification of 11-carbonyl-β-acetylboswellic acid

[0094] According to the extraction, separation and purification method of 11-carbonyl-β-acetylboswellic acid described in Example 2, 11-carbonyl-β-acetylboswellic acid was prepared by extraction, separation and purification.

[0095] 2. Preparation of 11-carbonyl-β-acetylboswellic acid derivative——11-carbonyl-β-acetylboswellic acid glucosamine:

[0096] Glucosamine free base solution (8.5ml, 0.4g) was added to 50ml of methanol solution of 2g of 11-carbonyl-β-acetylboswellic acid above, stirred at room temperature for 1 hour, filtered, and the filtrate was evaporated under reduced pressure and dried to obtain 11- Carbonyl-beta-acetylboswellic acid glucosamine.

[0097] 3. The composition of the prescription of the preparation

[0098] The composition of the tablet is 30 grams of 11-carbonyl-β-acetylboswellic acid glucosamine, 200 grams of pharmaceutical excipient starch, 67 grams of PVP,...

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Abstract

The invention discloses a preparation and an application of a pharmaceutic preparation of 11-carbonyl-betal- acetyl mastic acid and derivatives thereof extracted from frankincense, and the preparation is characterized by comprising the following steps: extracting, separating and purifying to obtain the 11-carbonyl-betal-acetyl mastic acid with the purity of 99% from the frankincense; and mixing the compound or the derivatives thereof with pharmaceutic adjuvants to prepare the pharmaceutically acceptable solid preparation and injection preparation. The pharmacological test result shows that the pharmaceutic preparation of the 11-carbonyl-betal-acetyl mastic acid and the pharmaceutic preparation of the derivatives thereof have obvious functions of analgesia, anti-inflammation, immunity regulation and the like, and can be applicable for treating patients suffering from rheumatic and rheumatoid arthritis.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to the preparation and application of a pharmaceutical preparation of 11-carbonyl-β-acetylboswellic acid extracted from frankincense and its derivatives. Background technique [0002] 11-Carbonyl-β-acetylboswellic acid is one of the important active ingredients contained in the gum-like resin of Boswellia carinii, a plant of the olive family. There are many reports on its research in foreign countries, but there are few real applications in the field of medicine. There are health foods containing 11-carbonyl-β-acetylboswellic acid and other boswellic acids on the market abroad, but they are not monomer compound preparations. At present, there are no preparations or drugs with 11-carbonyl-β-acetylboswellic acid as the active ingredient in the market at home and abroad. [0003] The research on the anti-inflammatory activity of 11-carbonyl-β...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00A61K31/56A61P29/00A61P19/02
Inventor 张玲凌沛学尚立霞
Owner 凌沛学
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