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Application of crocin in preparing hypnotic drug

A technology of crocin and crocetin, which is applied in the direction of drug combination, sugar derivatives, sugar derivatives, etc., can solve the problems of dependence and drug resistance, and achieve the effects of low dependence, low toxicity and good application prospects

Inactive Publication Date: 2012-01-04
FUDAN UNIV
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Problems solved by technology

[0004] Studies have shown that there is a significant difference between the sleeping patterns and physiological sleep waves induced by sleeping pills currently used clinically, suggesting that sleeping pills may have changed the normal sleep pattern of the human body, and the brain has not actually been fully rested. Drowsiness, dizziness, fatigue and other phenomena appear, and long-term use can also produce drug resistance, physical and psychological dependence

Method used

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  • Application of crocin in preparing hypnotic drug
  • Application of crocin in preparing hypnotic drug
  • Application of crocin in preparing hypnotic drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Sedation and hypnosis, improving sleep quality, and increasing the amount of non-rapid eye movement (non-rapid eye movements sleep, non-REM, NREM) sleep in mice

[0023] Experimental Materials

[0024] Male C57BL / 6J mice, SPF grade, 10-13 weeks old, 23-25g, were purchased from Shanghai Experimental Animal Center, Chinese Academy of Sciences. Breeding conditions: room temperature (22±1)°C, humidity (50±10)%, 12-hour light-dark rhythmic cycle, free access to water and food.

[0025] experimental method

[0026] Electrodes for recording electroencephalogram (EEG) and electromyography (EMG) were installed on the surface of the mouse skull, and the experiment was performed after the animal recovered for 10 days, and the electrode connecting wire was connected 3 days before the experiment. The administration groups are: vehicle (5% DMSO physiological saline) control group, three crocin high, medium and low dose groups, the doses are respectively: 100mg / kg, 30mg / kg and 10mg / ...

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Abstract

The invention belongs to the field of compound drugs, which relates to new drug application of crocin and a derivant thereof, in particular to application of crocin and a derivant in preparing a hypnotic drug and a health product. The crocin is ester formed by combining crocetin2-naphtholum8-sulfoacid with two-molecule gentiobiose with a chemical formula of C44H62O24 and molecular weight of 974.97. An animal experiment proves that the non-rapid eye movement sleep (slow wave sleep) time can be increased to treat insomnia or improve sleep quality, and the sleeping quantity is improved with dosedependent. The crocin and the derivant thereof can be used for preparing sedative-hypnotic drugs and health products and can be prepared into intestinal or non-intestinal combination drugs which comprise granules, tablets, liquid preparations, sustained release agents, medicinal granules, gelatin pearls, capsules or injections.

Description

technical field [0001] The invention belongs to the field of compound drugs, and relates to the new application of crocin and its derivatives, especially the application of crocin and its derivatives in the preparation of hypnotic drugs. Background technique [0002] One-third of life is spent in sleep, and sleep is as important as water, air, and food. With the acceleration of the industrialization process, the intensification of work pressure and social competition, night life and bad living habits, population aging and other reasons, according to the survey, one-third of the people in the world have sleep problems, and 5% of people completely rely on drugs to maintain sleep . According to the 2006 survey data in my country, 57% of people in Beijing, Shanghai and other six major cities have been troubled by insomnia in the past year. Sleep disorders are the cause of many diseases, and a considerable number of people are in a "sub-healthy" state. Although countries around...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7024A61P25/20C07H13/04
Inventor 黄志力曲卫敏里出良博
Owner FUDAN UNIV
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