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Method for testing quality of Discorea nipponica Makino in different places and medicinal materials of same genera

A quality inspection method, the technology of Dioscorea punctatus, is applied in the fields of pharmaceutical formulations, antipyretics, antitumor drugs, etc., and can solve problems such as rough quality standards

Inactive Publication Date: 2010-08-04
深圳市药品检验所
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

In addition, the existing quality standards of Dioscorea punctatus are relatively rough, and more perfect quality control methods need to be established

Method used

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  • Method for testing quality of Discorea nipponica Makino in different places and medicinal materials of same genera
  • Method for testing quality of Discorea nipponica Makino in different places and medicinal materials of same genera
  • Method for testing quality of Discorea nipponica Makino in different places and medicinal materials of same genera

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Embodiment Construction

[0019] The present invention is described in detail below in conjunction with accompanying drawing and specific embodiment, it should be pointed out that for those of ordinary skill in the art, without departing from the principle of the present invention, some improvements and modifications can also be made, these improvements and modifications It is also regarded as the protection scope of the present invention.

[0020] Experimental Materials:

[0021] Model 2695 High Performance Liquid Chromatograph (Waters, USA)

[0022] Model 2996 Diode Array Detector (Waters, USA)

[0023] Empower Workstation American Waters Corporation

[0024] BP210S electronic balance Germany Sartorius company

[0025] RE-52A rotary evaporator Shanghai Yarong Biochemical Instrument Factory

[0026] HH-2 digital display constant temperature water bath Changzhou Guohua Instrument Co., Ltd.

[0027] Methanol (chromatographically pure) Tianjin Concord Technology Co., Ltd.

[0028] Acetonitrile (chr...

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Abstract

The invention provides a method for testing the quality of Discorea nipponica Makino and medicinal materials of dioscorea in different places. The method comprises the following steps: using medicinal material powder to be tested to prepare sample solutions, testing under a certain chromatographic conditions, and calculating the content of the indexes of each sample through external standard method, and the method is characterized in that dioscin and protodioscin are used as the content determination indexes. Dioscin and protodioscin are the main saponins components of dioscorea medicinal material, are active ingredients of Discorea nipponica Makino for reducing blood fat and are very important to control the quality of medicinal materials and preparations. The invention adopts RP-HPLC analysis method to test the contents of dioscin and protodioscin in Discorea nipponica Makino and medicinal materials of dioscorea in different places; and the method is sensitive, accurate and targeted and can be used to control the quality of medicinal materials, extracts and corresponding preparations.

Description

technical field [0001] The invention relates to the field of quality detection of Chinese medicinal materials, in particular to a method for quality detection of Dioscorea chinensis and medicinal materials of the same genus from different origins. Background technique [0002] Dioscorea chinensis is used as medicine with its rhizomes, and its active ingredients are mainly steroidal saponins, including isospirostanol saponins such as dioscin and trillin, protodioscin and protodioscin (protogracillin) and other furostanol saponins. The average content of diosgenin (diosgenin, Dio) produced by hydrolysis of total saponins is 0.93%-2.26%. The water-soluble components are isolated from p-hydroxybenzyl tartaric acid (Piscidicacid), which has a strong antitussive effect. A small amount of 2,5-D-spirosta-3,5-diene (25-D-Spirosta-3,5-diene) is still isolated from the rhizome, in addition, it still contains glucose, rhamnose, sterol, allantoin , resin, starch and protein components...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P9/10A61P29/00A61P19/02A61P11/00A61P35/00A61P15/00G01N21/33A61K125/00
Inventor 王铁杰李军鲁艺文屏梁智渊肖丽和刘中博梁立娟毕开顺
Owner 深圳市药品检验所
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