Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of berberine in the preparation of drugs for preventing and treating rheumatoid arthritis

A technology of berberine, arthritis, applied in the field of traditional Chinese medicine

Inactive Publication Date: 2012-02-01
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Berberine, also known as berberine, is an isoquinoline alkaloid with antibacterial, anti-tuberculosis, anti-Leptospira, antiprotozoal, sedative, antipyretic, blood pressure-lowering, and choleretic effects. Has been reported for the treatment of rheumatoid arthritis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of berberine in the preparation of drugs for preventing and treating rheumatoid arthritis
  • Application of berberine in the preparation of drugs for preventing and treating rheumatoid arthritis
  • Application of berberine in the preparation of drugs for preventing and treating rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 berberine animal efficacy test

[0018] 1. Experimental materials

[0019] Drugs and Reagents

[0020] Berberine: purchased from China National Institute of Pharmaceutical and Biological Products, dissolved in 3‰ CMC-Na solution to a 1 mg / ml solution. Different volumes were intraperitoneally injected according to the body weight of the animals. Chicken type II collagen (CII): Chondrex, Redmond, WA 98052, USA; Incomplete Freund's Adjuvant (IFA) Difco Laboratories, Detroit, MI; Phosphate buffered saline (PBS): self-prepared by our laboratory, in 800ml Dissolve 8gNaCl, 0.2g KCl, 1.44g Na in distilled water 2 HPO 4 and 0.24g KH 2 PO 4 . Use hydrochloric acid to adjust the pH to 7.4, add water to make up to 1L, and use after filter sterilization; DMSO dimethyl sulfoxide (Dimethylsulfoxide, DMSO): a product of Sigma Company; 1640 medium: Gino Biomedical Technology Co., Ltd.; Calf Serum: Minhai Biological Co., Ltd.; 96-well flat bottom plate, CORNING; 70 μ...

Embodiment 2

[0054] Tablets: Berberine 20g

[0055] Lactose 177g

[0056] Cornstarch 50g

[0057] Magnesium Stearate 3g

[0058] Preparation method: mix berberine, lactose and starch, moisten evenly with water, sieve the wet mixture and dry it, then sieve it, add magnesium stearate, then press the mixture into tablets, each tablet weighs 250mg, Berberis The alkali content is 20mg.

Embodiment 3

[0060] Ampoule: Berberine 10g

[0061] Sodium chloride 9g

[0062] Preparation method: dissolve berberine and sodium chloride in an appropriate amount of water for injection, filter the resulting solution, and fill it into ampoules under aseptic conditions, each containing 10 mg of berberine.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides the application of berberine in the preparation of medicines for preventing and treating rheumatoid arthritis. The invention adopts the berberine to carry out the animal efficacy test, and the result shows that the berberine can inhibit the clinical onset of collagen-induced arthritis, and obviously inhibit the severity and incidence rate of the onset. And can down-regulate tumor necrosis factor α, interleukin 17, interferon γ in spleen cell supernatant, inhibit the secretion of pro-inflammatory cytokines TNF-α, IFN-γ and IL-17, so as to prepare drugs for preventing and treating rheumatoid arthritis, It has great clinical application value. The medicine is a pharmaceutical composition made of berberine as an active ingredient and conventional pharmaceutical excipients, including tablets, dispersible tablets, buccal tablets, orally disintegrating tablets, sustained-release tablets, capsules, soft capsules, dropping pills, Granules, injections, powder injections or aerosols.

Description

technical field [0001] The invention relates to traditional Chinese medicines, in particular to the application of berberine in the preparation of medicines for preventing and treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (Rheumatoid Arthritis, RA) is a chronic systemic inflammatory disease of unknown etiology, with chronic, symmetrical, polysynovial arthritis and extra-articular lesions as the main clinical manifestations, belonging to autoimmune inflammatory diseases disease. The disease is prone to occur in small joints such as hands, wrists, and feet, and recurs in a symmetrical distribution. In the early stage, joints are red, swollen, hot, painful, and dysfunctional. In the late stage, joints may be stiff and deformed in varying degrees, accompanied by atrophy of bones and skeletal muscles, which is very easy to cause disability. From the perspective of pathological changes, rheumatoid arthritis is a disease that mainly involves th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4375A61P19/02A61P29/00
Inventor 胡振林张卫东苏娟柳润辉沈云亨李慧梁徐希科焦晴晴
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com