Methods and compositions for the diagnosis and treatment of esphageal adenocarcinomas

A kind of technology of esophageal adenocarcinoma, esophagus, applied in [0006 field, can solve the problems such as difficult and effective diagnosis and treatment of disease

Inactive Publication Date: 2010-10-13
THE OHIO STATE UNIV RES FOUND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0016] Despite considerable research into therapies to treat these diseases, these diseases remain difficult to diagnose and treat effectively, and the observed mortality rates among patients suggest that improvement is needed in the diagnosis, treatment and prevention of the disease

Method used

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  • Methods and compositions for the diagnosis and treatment of esphageal adenocarcinomas
  • Methods and compositions for the diagnosis and treatment of esphageal adenocarcinomas
  • Methods and compositions for the diagnosis and treatment of esphageal adenocarcinomas

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Embodiment

[0087] Using cancerous tissue (CT) and non-cancerous tissue (NCT) resected from patients divided into training and validation sets, we first generated miRNA microarrays 35Profiles were followed by qRT-PCR to confirm differential expression of relevant miRNAs in all samples. The clinical characteristics of all patients were Figure 5 -Summary in Table 1.

[0088] No differences between clinical variables in the two cohorts were observed for ADC patients, whereas differences in sex and stage were observed between cohorts of SCC patients. The microRNA microarray expression values ​​in the training group samples were first evaluated, followed by qRT-PCR to confirm the microRNA microarray expression values ​​of all samples.

[0089] Differential expression of microRNAs in ADC cases

[0090] Changes in miRNA microarray expression levels specific to ADC patients were assessed in 32 CT and adjacent NCT pairs. Image 6 - The upper panel of Table 2 lists differentially expressed miR...

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Abstract

Methods and compositions for the diagnosis, prognosis and / or treatment of esophageal adenocarcinoma and Barrett's esophagus associated adenocarcinoma are disclosed, along with more markers where a difference is indicative of esophageal adenocarcinoma and squamous cell carcinoma, and / or Barrett's esophagus associated adenocarcinomas or a predisposition thereto. The invention also provides methods and compositions of identifying anti-cancer agents therefor.

Description

[0001] Inventors: Carlo M. Croce, Curtis C. Harris, Ewy A Mathè [0002] Cross References to Related Applications [0003] This application claims the benefit of US Provisional Application No. 60 / 979,300, filed October 11, 2007, the entire disclosure of which is expressly incorporated herein by reference. [0004] Statement Regarding Federally Sponsored Research [0005] This invention was made with Government support under National Cancer Institute Grant No. -------. The Government has certain rights in this invention. [0006] Technical field and industrial applicability of the invention [0007] The present invention relates generally to the field of molecular biology. More particularly, methods and compositions related to biomarkers involved in esophageal cancer and Barrett's esophagus. Certain aspects of the invention include use in the diagnosis, treatment and prognosis of Barrett's esophagus and esophageal carcinoma, including adenocarcinoma and squamous cell carcino...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C12P19/34C07H21/02
CPCC12Q2600/178C12Q2600/112C12Q1/6886C12Q2600/106C12Q2600/158A61P1/04A61P35/00
Inventor C·M·克劳斯C·C·哈里斯E·A·玛特赫
Owner THE OHIO STATE UNIV RES FOUND
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