Temperature sensor and biosensor using the same
A technology of temperature sensor and predetermined temperature, which is applied in the field of biosensors, can solve problems such as protein denaturation and prevent measurement, and achieve the effect of improving performance
Inactive Publication Date: 2010-10-20
KONINK PHILIPS ELECTRONICS NV
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Problems solved by technology
Also, at high temperatures, proteins may denature, preventing measurements from being performed correctly
Method used
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[0044] The present invention will be described with respect to particular embodiments and with reference to the accompanying drawings but the invention is not limited thereto but only by the claims. Any reference signs in the claims should not be construed as limiting the scope. The drawings described are only schematic and not restrictive. In the drawings, the size of some of the elements may be exaggerated and not drawn on scale for illustrative purposes. When the word "comprising" is used in the present description and claims, it does not exclude other elements or steps. Where an indefinite or definite article is used when referring to a singular noun such as "a", "an", "the", this also includes a plural of that noun unless expressly stated otherwise.
[0045] Furthermore, the words first, second, third etc. appearing in the description and claims are only used to distinguish similar elements and not necessarily to prescribe order or chronological order. It is to be unde...
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Abstract
Embodiments of the invention relates to a temperature sensor and an analytical device comprising the same. The temperature sensor comprises a carrier (11) with a detection surface (12) on which temperature indicating agents (14) are present and, optionally, at which target components can collect and optionally bind to specific capture elements. An incident light beam (Ll) is transmitted into the carrier and evanescent wave excitation is inducedat the detection surface (12). The amount of light in the reflected light beam (L2) or an optical, e.g. luminescence response is then detected by a light detector (31). In one example, evanescent light is affected (absorbed, scattered) by temperature indicating agents and optionally target components and / or label particles at the binding surface (12) and will therefore be missing in a frustrated total internal reflected light beam (L2). This can be used to determine the temperature of the detection area and optionally the amount of target components at the binding surface (12) from the amount of light in the reflected light beam (L2, L2a, L2b). A magnetic field generator (41) is optionally used to generate a magnetic field (B) at the binding surface (12) by which magnetic label particles (1) can be manipulated, for example attracted or repelled.
Description
technical field [0001] The present invention relates to a temperature sensor and an analysis device using the same. In particular, the invention enables rapid and precise measurement of temperature and / or its distribution at the level of the temperature detection surface. The invention also relates to a biosensor, such as an FTIR biosensor device, comprising an optical detection region with an integrated temperature monitoring and / or control module. Background technique [0002] Accurate temperature determination at the level of the device surface where action occurs during application is an important concept in a wide range of technologies. This is especially the case, for example, in the field of biosensors where sensing at or near a sensing surface can be very temperature dependent. The complex binding of specific target biological compounds, such as, but not limited to, DNA, RNA or protein. As this binding is temperature dependent, the resulting detection of the pres...
Claims
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IPC IPC(8): G01K11/00G01K11/12
CPCG01K11/125G01K11/00
Inventor R·彭特曼S·范利洛普A·H·J·伊明克D·J·布勒尔
Owner KONINK PHILIPS ELECTRONICS NV