Preparation process of dissolvable hemostatic gauze

A preparation process and gauze technology are applied in the field of preparation technology of dissolving hemostatic gauze, which can solve the problems of toxic and side effects of drugs and unsatisfactory hemostatic effect, and achieve the effects of no toxic and side effects, promoting wound healing and protecting wound surfaces.

Inactive Publication Date: 2014-04-23
安徽大江医疗用品有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are two main research directions for hemostatic gauze: one is to focus on the hemostatic effect and the speed of its function, represented by developed countries such as the United States and Germany, which mainly use the drug components with hemostatic function to treat the gauze, and realize it with the help of drugs. The advantage of hemostasis is that the hemostatic effect is good and the effect is rapid, but the disadvantage is that the drug has unavoidable side effects on the human body; the second is to focus on the research on the solubility of gauze to prevent wound adhesion and secondary pollution after use. Some degradable gauzes have come out, and their hemostatic mechanism is mainly to stop bleeding by compression. In fact, the hemostatic function of platelets is still used. Therefore, for bleeding patients with less platelets and coagulation dysfunction, the hemostatic effect is not ideal.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Prepare 3 kg of dissolved hemostatic gauze as follows:

[0021] (1) 10L of sodium hydroxide solution with a concentration of 15% (percentage by weight) and 20L of ethanol solution with a concentration of 25% (percentage by volume) were added to the reaction tank, and stirred to obtain 30L mixed solution I;

[0022] (2) drop into 3kg absorbent cotton gauze in mixed solution I, stir 90min;

[0023] (3) 11.5L of chloroacetic acid solution with a concentration of 10% (percentage by weight) and 18.5L of ethanol solution with a concentration of 4% (percentage by volume) are configured into 30L mixed solution II;

[0024] (4) Add the mixed solution II evenly dropwise into the reaction tank within 60 minutes with a burette, and continue to stir for 180 minutes, during which attention should be paid to prevent the gauze from being entangled, so as not to affect the uniformity of the gauze;

[0025] (5) Take out a piece of gauze with a size of about 50mm×50mm from the reaction t...

Embodiment 2

[0033] Prepare 4.5 kg of dissolved hemostatic gauze as follows:

[0034] (1) 10L of sodium hydroxide solution with a concentration of 20% (percentage by weight) and 20L of ethanol solution with a concentration of 30% (percentage by volume) were added to the reaction tank, and stirred to obtain 30L mixed solution I;

[0035] (2) drop into 4.5kg absorbent cotton gauze in mixed solution I, stir 90min;

[0036] (3) 11.5L of chloroacetic acid solution with a concentration of 15% (percentage by weight) and 18.5L of ethanol solution with a concentration of 5.5% (percentage by volume) are configured into 30L mixed solution II;

[0037] (4) Add the mixed solution II evenly dropwise into the reaction tank within 60 minutes with a burette, and continue to stir for 180 minutes, during which attention should be paid to prevent the gauze from being entangled, so as not to affect the uniformity of the gauze;

[0038] (5) Take out a piece of gauze with a size of about 50mm×50mm from the reac...

Embodiment 3

[0046] Prepare 6 kg of dissolved hemostatic gauze as follows:

[0047] (1) 10L of sodium hydroxide solution with a concentration of 25% (percentage by weight) and 20L of ethanol solution with a concentration of 35% (percentage by volume) were added to the reaction tank, and stirred to obtain 30L mixed solution I;

[0048] (2) throw 6kg absorbent cotton gauze in mixed solution I, stir 90min;

[0049] (3) 11.5L of chloroacetic acid solution with a concentration of 20% (percentage by weight) and 18.5L of ethanol solution with a concentration of 7% (percentage by volume) are configured into 30L mixed solution II;

[0050] (4) Add the mixed solution II evenly dropwise into the reaction tank within 60 minutes with a burette, and continue to stir for 180 minutes, during which attention should be paid to prevent the gauze from being entangled, so as not to affect the uniformity of the gauze;

[0051](5) Take out a piece of gauze with a size of about 50mm×50mm from the reaction tank a...

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PUM

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Abstract

The invention discloses a preparation process of a dissolvable hemostatic gauze, which takes absorbent cotton gauze as the main raw material, and processes the raw material by sodium hydroxide solution, chloroacetic acid solution, ethanol solution and the like to prepare the dissolvable hemostatic gauze which has good dissolubility, can be absorbed by human body without toxic and side effect, does not pollute environment and has good and rapid hemostasis effect. The dissolvable hemostatic gauze has good hemostasis effect on traumatism, cortex bleeding, bleeding caused by muscle strain and postoperative bleeding of brain and ambition surgery, particularly has good hemostasis effect on the bleeding caused by less blood cells and cruor dysfunction of a patient.

Description

technical field [0001] The invention relates to a medical dressing, in particular to a preparation process for dissolving hemostatic gauze. Background technique [0002] Gauze is widely used in the field of medical and health care, and is mainly used for stuffing and bandaging wounds to stop bleeding in a short period of time. At present, there are two main research directions for hemostatic gauze: one is to focus on the hemostatic effect and the speed of its function, represented by developed countries such as the United States and Germany, which mainly use the drug components with hemostatic function to treat the gauze, and realize it with the help of drugs. The advantage of hemostasis is that the hemostatic effect is good and the effect is rapid, but the disadvantage is that the drug has unavoidable side effects on the human body; the second is to focus on the research on the solubility of gauze to prevent wound adhesion and secondary pollution after use. Some degradable...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/62
Inventor 杨庆李柏林
Owner 安徽大江医疗用品有限责任公司
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