Antibodies against PD-1 and uses therefor

A PD-1 and antibody technology, applied in the direction of antibodies, applications, anti-inflammatory agents, etc., can solve problems such as weakening of T cell response
CN101899114AInactive Publication Date: 2010-12-01WYETH LLC +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WYETH LLC
Publication Date
2010-12-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

This disclosure provides antibodies and antigen-binding fragments that can act as agonists and / or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.
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Description

[0001] This application is a divisional application of the invention patent application titled "anti-PD-1 antibody and its use" with the international application PCT / IB2003 / 006304 entered into China with the international filing date on December 22, 2003 and the application number 200380109929.8. technical field

[0002] The technical field relates to the modulation of immune responses regulated by the programmed death 1 (PD-1) receptor. Background technique

[0003] The adaptive immune response involves the activation, selection and clonal expansion of two classes of lymphocytes called T cells and B cells. After encountering an antigen, T cells proliferate and differentiate into antigen-specific effector cells, while B cells proliferate and differentiate into antibody-secreting cells.

[0004] T cell activation is a multistep process requiring several signaling events between T cells and antigen presenting cells (APCs). For T cell activation to occur, two types of signals...

Claims

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