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Positioning of magnetic coils in a sensor device

A sensor device and magnetic coil technology, applied in electromagnetic measurement devices, measurement devices, electrical devices, etc., can solve the problems of reducing light, violating total internal reflection, etc., and achieve good spatial resolution, repeatable measurement, and low cost. Effect

Inactive Publication Date: 2010-12-01
KONINK PHILIPS ELECTRONICS NV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if a bead 12 or other detection label is bound to the sensor surface 11, the condition of total internal reflection will be violated and part of the light will be scattered into the sensor chamber or cartridge 1 and thus reduce the light reflected by the sensor surface 11. amount
By measuring the intensity of the reflected light using a photodetector, it is possible to estimate the amount of beads 12 bound to the binding sites on the sensor surface 11

Method used

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  • Positioning of magnetic coils in a sensor device
  • Positioning of magnetic coils in a sensor device
  • Positioning of magnetic coils in a sensor device

Examples

Experimental program
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Embodiment Construction

[0021] figure 2 Three magnetic coils 2, 3, 3' for exciting paramagnetic label beads 12 in an FTIR biosensor device are schematically shown. The sensor cartridge 1 includes a sensor chamber and a sensor surface 11, similar to figure 1 As shown in , the sensor chamber and sensor surface 11 are arranged between the top coil 2 and the bottom coil 3, 3'. Such as figure 2 As illustrated, the top coil 2 is involuntarily offset, i.e. displaced in the horizontal direction with respect to said bottom coils 3, 3'.

[0022] when in figure 2 In the case shown in , the magnetic induction of the two bottom coils 3 and 3' is measured by applying a current to the top coil 2 and measuring the voltage caused by the electromagnetic field generated by the current in the two bottom coils 3, 3', it will be observed that Due to the offset, the mutual inductance M between the top coil 2 and the left bottom coil 3 23 and the mutual inductance M between the top coil 2 and the right bot...

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Abstract

The invention provides for a method for determining the relative position ofat least two magnetic actuator coils (2,3,3') in a sensor, said coils being arranged on substantiallyopposite sides of a sensor cartridge (1). By- measuring the electromagnetic induction of one of the coils, the relative positionsof the coils in the sensor device is determined. Based on the determined relative positions, these positions may be adjusted. Alternatively, the actuation currents in the magnetic coils may be adjusted based on the determined relative positions. Furthermore, a sensor device comprising a sensor cartridge, at least two magnetic coils arranged on substantiallyopposite sides of the sensor cartridge, and measuring means for determining the electromagnetic induction is provided.

Description

technical field [0001] The present invention relates to a sensor device comprising at least two magnetic coils arranged above and below a sensor chamber, such as a frustrated total internal reflection (FTIR) biosensor device, and in particular to the positioning of the magnetic coils. Background technique [0002] Currently, there is an increasing demand for biosensors. In general, biosensors are capable of detecting a given specific molecule within an analyte, where the amount or concentration of the target molecule is usually small. For example, the amount of drugs or cardiac markers in saliva or blood can be measured. Drugs of abuse are generally small molecules possessing only one epitope and for this reason cannot be detected by eg sandwich assays. Competitive assays or inhibition assays are preferred methods for detecting these molecules. A well-known competitive assay setup is to couple the target molecule of interest to a surface and attach the antibody to a detec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/55G01B7/00
CPCG01B7/003G01N21/552
Inventor J·A·H·M·卡尔曼
Owner KONINK PHILIPS ELECTRONICS NV