Quick titling mirror-based wide view field confocal scanning microscope

A technology of confocal scanning and wide field of view, which is applied in the field of microscopy, can solve the problems of simultaneous imaging of high resolution and large field of view, and achieve improved operability and initiative, enhanced imaging initiative, and imaging vision. The effect of field increase

Active Publication Date: 2010-12-08
SUZHOU MICROCLEAR MEDICAL INSTR
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  • Abstract
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  • Application Information

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Problems solved by technology

[0006] The technical problem of the present invention is to overcome the limitation that the traditional confocal scanning microscope cannot realize sim

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  • Quick titling mirror-based wide view field confocal scanning microscope
  • Quick titling mirror-based wide view field confocal scanning microscope
  • Quick titling mirror-based wide view field confocal scanning microscope

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Embodiment Construction

[0012] According to the manual attached figure 1 How to implement the function of the wide-field confocal scanning microscope based on the fast tilting mirror proposed by the present invention is described in detail as follows:

[0013] 1. The laser light source (1) of the light source module is connected to the optical fiber (2) through the fiber coupler, and the laser is transmitted through the optical fiber (2). The end of the optical fiber is placed at the focal position of the coupling lens (3), and the coupling lens (3) , the laser light exits in the form of parallel light, passes through the mirror (4), and enters the beam splitter (5). The beam splitter (5) of the present invention is generally a beam splitter with high transmittance and low reflectance, and the ratio of the transmittance to the reflectance is generally 9:1. The high transmittance is to ensure that the signal light energy returned from the human eye enters the photodetector part through the beam split...

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Abstract

The invention discloses a quick titling mirror-based wide view field confocal scanning microscope, consisting of a light source assembly, a two-dimensional imaging scanning assembly, a wide view field scanning assembly and a detector assembly. The confocal scanning microscope device preferably uses the design of a spherical reflector telescope to avoid the high-order aberration of the system and simultaneously compensates the low-order aberration of the system by using a cylindrical lens. By using the synchronous work of the quick tilting mirror and the two-dimensional scanning imaging assembly, a high-resolution image at the eye bases of human eyes (or a sample additionally provided with an objective lens) in a wide view field range can be acquired by using an automatic splicing technology on the basis of acquiring a single-frame image in a small view field. The invention mainly overcomes the difficulty that the high resolution and the wide view field synchronously image, realizes the wide view field confocal scanning microscope with compact design, high imaging resolution and wide imaging view field and greatly improves the imaging view field and the imaging quality of the traditional confocal microscope. Therefore, the invention can realize the high-resolution imaging on the eye base of the human eye (or a sample to be detected) in the large view field range.

Description

technical field [0001] The invention relates to a microscope, in particular to a wide-field confocal scanning microscope based on a fast tilting mirror, which can perform confocal scanning and high-resolution imaging of biological tissues within a large field of view. Background technique [0002] Confocal microscope technology was first applied to biological tissue imaging (Webb RH, Hughes GW. Scanning Laser Ophthalmoscope. Biomedical Engineering, IEEE Transactions on. 1981, BME-28(7): 488-92.), and developed into a mature one in 1987. Laser confocal scanning imaging equipment (Webb R, Hughes G, Delori F. Confocal scanning laser ophthalmoscope. Applied optics. 1987; 26(8): 1492-9). [0003] The invention patent with the patent number US4863226 (1989) proposed the concept of laser confocal scanning imaging. This patent realizes the horizontal scanning of the sample through the acousto-optic modulator, and realizes the vertical scanning of the sample through another scanning ...

Claims

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Application Information

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IPC IPC(8): A61B3/13A61B3/14G01N21/00
Inventor 李超宏
Owner SUZHOU MICROCLEAR MEDICAL INSTR
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