Novel application of trefoil factor 3
A technology of trefoil factor and heroin, applied in medical preparations containing active ingredients, peptide/protein ingredients, drug combinations, etc.
Active Publication Date: 2010-12-08
PEKING UNIV
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AI Technical Summary
Problems solved by technology
At present, there is no relevant research on the use of TFF3 for drug addiction detoxification
Method used
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Embodiment 1
[0020] Example 1, The therapeutic effect of TFF3 administration on urging withdrawal in morphine-dependent mice
[0021] 1. Experimental materials and animals
[0022] Recombinant rat intestinal trefoil factor (recombinant rat TFF3) (purchased from Beijing Yongkang Jiaxin Biotechnology Co., Ltd., product batch number: 002010011101, the amino acid sequence of the recombinant rat intestinal trefoil factor is the sequence in the sequence listing 1.) and clonidine (positive control, clonidine company), were dissolved in 0.9% normal saline, respectively, intraperitoneal injection administration.
[0023] Morphine hydrochloride (Qinghai Pharmaceutical Factory), adopts subcutaneous injection mode.
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The invention discloses novel application of a trefoil factor 3. The invention provides the novel application of the trefoil factor 3 in preparing products for treating drug addiction. The invention relates to application of TFF3 (trefoil factor family 3) in morphine-dependent mice precipitated withdrawal tests and reflects the treatment effect of the TFF3 on morphine addiction withdrawal by observing jump times and weight loss of mice subjected to acute precipitated withdrawal.
Description
technical field [0001] The invention relates to a new application of trefoil factor 3. Background technique [0002] Drug addiction is a major public health and social problem that plagues global human health and social development. It seriously endangers human health, affects family stability and social development, and causes huge economic losses to society. For example, in 2007, about 42% of the newly infected cases of AIDS in my country were related to drug addiction and abuse. [0003] Drug addiction is a chronic high-relapse complex brain disease characterized by progressive development from impulsive drug-seeking caused by initial drug use to compulsive drug-seeking, resulting in strong physical and mental dependence. Long-term drug use can cause dysfunction of the body and histopathological changes, accompanied by drowsiness, insensitivity, movement disorders, hallucinations and delusions, etc., resulting in mental disorders. Due to the addictive nature of drugs, i...
Claims
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IPC IPC(8): A61K38/17A61P25/36
Inventor 陆林史海水朱维莉孙成玉罗宜孝
Owner PEKING UNIV