Quaternary ammonium salt of chitosan and application thereof

A technology of chitosan quaternary ammonium salt and chitosan, which is applied in the direction of prosthesis, coating, medical science, etc., to achieve the effect of preventing infection and preventing massive colonization

Inactive Publication Date: 2012-05-02
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no report on the biocompatibility of chitosan with bone after quaternization

Method used

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  • Quaternary ammonium salt of chitosan and application thereof
  • Quaternary ammonium salt of chitosan and application thereof
  • Quaternary ammonium salt of chitosan and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] 1. Materials and methods

[0030] (1) Experimental materials and instruments

[0031] Material: Chitosan quaternary ammonium salt (HAAC, DS: 37.3%, 56.0%, 81.5%) is made of chitosan (Mw=2.0×105, degree of deacetylation: 91.83%, Zhejiang Yuhuan Marine Biochemical Co., Ltd.) and 2 , 3-epoxypropyltrimethylammonium chloride (purity: 96%, Shandong Sangong Chemical Co., Ltd.) synthesis, soybean protein tryptone medium (Trypticase Soy Broth, TSB, British OXOID company), other reagents are Commercially available analytical reagents.

[0032] Instruments: clean bench, BIO-HAZARD, VCM-420, Taiwan, China; electronic analytical balance, METTLER TOLEDO, AB204-E, Switzerland; electromagnetic stirrer, STUART, SM24, UK; cryogenic centrifuge, UNIVERSAL, 32R, HETTICH , Germany; ELISA, MULTISKAN, ASCENT, V1.22, USA.

[0033] 6% HACC purified chitosan and 2,3-epoxypropyltrimethylammonium chloride were synthesized according to the ratio of (n(CS) / n(GTMAC)=2 / 1(mol / mol)); 18%HACC Purified...

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Abstract

The invention relates to a quaternary ammonium salt of chitosan and application thereof. A substitution value of the quaternary ammonium salt of chitosan is 6-44 percent. As an optimized technical scheme, the substitution value of the quaternary ammonium salt of chitosan is 18 percent. The invention also provides new application of the quaternary ammonium salt of chitosan. The invention not only invents the anti-infective effect of the quaternary ammonium salt of chitosan with the substitution value of 6-44 percent, but also invents the influence on cell proliferation, osteogenic differentiation and osseointegration, thereby more comprehensively reflecting the application effect of the quaternary ammonium salt of chitosan with the substitution value of 6-44 percent. The quaternary ammonium salt of chitosan with the substitution value of 6-44 percent can be expected to exert the anti-infective function on surface coating layers of various metal implants of osteopathic joint prosthesis,nail plates, intramedullary nails, and the like and can be additionally used as bone substitute materials, wound dressing materials, and the like to play a role.

Description

【Technical field】 [0001] The invention relates to the technical field of medical materials, in particular to a chitosan quaternary ammonium salt and an application thereof. 【Background technique】 [0002] Postoperative infection of orthopedic implants is a serious complication of this type of surgery. Due to the existence of large metal implants, this type of infection has special characteristics: the area around the implants has low immunity, and pathogenic bacteria can easily adhere and multiply on the surface of the implants. Form an infection focus; even some low-virulence opportunistic pathogens can easily cause this type of disease, such as Staphylococcus epidermidis as a pathogen in 32% of such infections. According to statistics, the infection rate of joint replacement is between 0.5-5%, while the postoperative infection rate of open fracture is as high as 5-33%, and can lead to osteomyelitis and sepsis. Infection has been reported to be the second leading cause of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08A61L27/34A61L27/54
Inventor 彭兆祥郭圣荣汤亭亭汪灵
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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