Composite anesthetic, preparation method thereof, and use thereof in myocardial infarction animal model

An anesthetic, chloral hydrate technology, applied in the direction of anesthetics, active ingredients of hydroxyl compounds, active ingredients of heterocyclic compounds, etc., can solve problems such as injury to lung tissue, lung infection, affecting animal airway ventilation, etc., and achieve inhibition of respiratory glands. body secretion, reducing the degree of airway obstruction and improving the survival rate of rats
CN101947223BInactive Publication Date: 2013-05-22THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
Publication Date
2013-05-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a composite anesthetic, a preparation method thereof and use thereof in a myocardial infarction animal model. The composite anesthetic consists of aqueous solution of pentobarbital sodium, aqueous solution of chloralic hydras, and aqueous solution of atropine or an anticholinesterase medicament. The invention has the advantages that: 1, by adopting the composite anesthetic solution, particularly the composite anesthetic solution with a proper amount of atropine, the secretion of the respiratory glands can be inhibited effectively, the air passage blockage degree can be lowered and the survival rate of rats can be improved; and 2, the composite anesthetic has the advantages of low price, simple operation, high rat survival rate, high myocardial infarction success rate, reliable effect and the like, can be used as a normal anesthetic for rat myocardial infarction animal models and provides an instructive anesthetic scheme for surgeries on other small animals. The composite anesthetic, the preparation method thereof and the use thereof are applicable in the field of basic medical animal research and related fields.
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Description

technical field

[0001] The invention relates to the technical field of anesthetics, preparation methods thereof and application in animal models of myocardial infarction, and relates to a compound anesthetic, preparation methods thereof and application in animal models of myocardial infarction. Background technique

[0002] Ischemic heart disease - insufficient blood flow to the heart muscle - is the leading cause of death in the world, including most low- and middle-income countries. In the field of cardiac ischemic diseases, the establishment of animal models is widely used in pathogenesis, drug therapy, and cell therapy. According to different research purposes, the selection of animal platforms is also different. Moreover, the successful establishment of animal models is a key factor. As the first step in the experimental study, coronary artery ligation can cause relatively consistent infarction sites, and the left ventricular function and pathophysiological changes are ...

Claims

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