DNA sequence similarity detecting method based on Hurst indexes

A DNA sequence and detection method technology, applied in the direction of electrical digital data processing, special data processing applications, instruments, etc., to achieve the effect of simplifying the calculation complexity, concise method, and improving the degree of discrimination

Inactive Publication Date: 2011-01-19
CHONGQING UNIV
View PDF4 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the Hurst index is not applied to DNA sequence similarity analysis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • DNA sequence similarity detecting method based on Hurst indexes
  • DNA sequence similarity detecting method based on Hurst indexes
  • DNA sequence similarity detecting method based on Hurst indexes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0028] With reference to the accompanying drawings, the first exon coding sequence of the beta-globulin used in 11 species by the method of the present invention will be described in detail as the analysis object as an example, including the following steps: see figure 1 , the DNA sequence similarity detection method based on the Hurst index of the present embodiment comprises the following steps:

[0029] 1) The coding sequence of the first exon of β-globin, which is widely used in the analysis of sequence similarity, was selected as the initial sequence; see Table 1.

[0030] 2) Digitally convert the initial sequence obtained in step 1) to obtain the corresponding numerical sequence of the initial sequence; this method adopts 2D graphic representation to digitize the DNA sequence (see M, M, N, et al. Chemical Physics Letters [J]., 2003, 368: 1-6.). The characteristic of this method is that the expression of 4 bases depends on the sequence in which they appear in the an...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the field of biological information processing, in particular to a DNA sequence similarity detecting method based on Hurst indexes, which can simultaneously detect the similarity of a plurality of DNA sequences, simplifies the computational complexity, improves the operational efficiency, and can increase the difference degree among analysis objects of nearer evolutionary distance. The method comprises the following steps: (1) acquiring DNA coding sequences of different species in the same function area as initial sequences; (2) carrying out digital conversion on the initial sequences acquired in the step (1) to acquire numerical sequences corresponding to the initial sequences; (3) analyzing each numerical sequence acquired in the step (2) by a R / S analysis method to acquire Hurst indexes of each numerical sequence; (4) constructing a distance matrix by utilizing the Hurst indexes acquired in the step (3); and (5) acquiring sequence similarity information from the distance matrix acquired in the step (4).

Description

technical field [0001] The invention relates to the field of biological information processing, in particular to a DNA sequence similarity detection method. Background technique [0002] An important content of bioinformatics is sequence analysis. By analyzing the sequences of nucleic acids and proteins, their structural and functional information is obtained to understand the functions of nucleic acids and proteins in organisms and to study their evolutionary origins. The rapid expansion of sequence data in sequence databases has prompted researchers to conduct extensive research on sequence analysis methods. [0003] Based on different sequence expression methods, researchers use a variety of algorithms to extract characteristic parameters that can effectively reflect sequence biological information from digital sequences, such as the largest eigenvalue and topological index of various matrices, and then construct a multidimensional vector corresponding to the analysis seq...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G06F19/00
Inventor 刘晓唐鸿铃黄扬帆曾浩刘玲
Owner CHONGQING UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap