Device and method for treating tumors through irreversible electroporation
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A kind of tumor, reverse electricity technology, applied in the field of tumor treatment
Active Publication Date: 2011-02-16
CHONGQING UNIV
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The main disadvantages of this device and method are: chemotherapy is the main treatment, and the electroporation treatment system plays an auxiliary role in enhancing the curative effect of chemoth
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Embodiment 1
[0043] Such as Figure 1~6 As shown, a device for treating tumors by irreversible electroporation mainly includes a square wave pulse generation and measurement system, a signal conversion system, a man-machine communication system, a measurement and control system, and a power supply system.
[0044] The square wave pulse generation and measurement system mainly includes a high-voltage constant-current power supply (input is 220V / 50Hz alternating current, output direct current with the highest voltage amplitude of 4000V and the maximum current amplitude of 60mA) 12, the first vacuum relay (model G41A , a pair of normally open contacts, the maximum withstand voltage is 5000V, the maximum conduction current is 30A under DC conditions, the maximum conduction current is 100A under pulse conditions, and the maximum operating current is above 100mA) 8 and the second vacuum relay (model G41C, A pair of normally open contacts and a pair of normally closed contacts, the maximum withst...
Embodiment 2
[0051] Such as Figure 7 As shown, a method for treating tumors by irreversible electroporation, using the device and treatment electrodes of Example 1, the specific method steps for treating tumors through procedures are as follows:
[0052] (1) Initialization
[0053] After the device of embodiment 1 was powered on 14 boots, the yellow indicator light 2 of "waiting" state was on, and the system was initialized; then the liquid crystal display screen 1 entered the parameter setting interface (the parameters set included pulse amplitude, repetition frequency, Pulse width and number of pulses), the initial parameters displayed are pulse amplitude 2000V, repetition frequency 1Hz, pulse width 100μs, and number of pulses 100.
[0054] (2) Determine the treatment parameters
[0055] After step (1) is completed, first formulate a corresponding treatment plan according to the characteristics of the patient (physical condition, age, gender) and the specific conditions of the tumor t...
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Abstract
The invention relates to a device and a method for treating tumors through irreversible electroporation, belonging to the technical field of tumor treatment. The device mainly comprises a square wave pulse generation and measurement system, a signal conversion system, a man-machine communication system, a measurement control system and a power supply system. In the method, the device and a therapeutic electrode are used for treating the tumors through a program. Under the circumstance of no injection of chemotherapeutic drugs, microsecond square wave pulses are applied to tumor tissues, the entire tumor cell is fully damaged, so that the tumor cell dies due to irreversible electroporation, and the harm on the body of a patient caused by the side effect of the chemotherapeutic drugs is radically avoided. The invention has the characteristics of short treatment time, no pain, good treatment effect, high safety, convenient use, simple operation, convenient popularization and application and the like. The device and the method can be widely used for treating the tumors of human and animals, and are especially applicable to human tumor treatment.
Description
technical field [0001] The invention belongs to the technical field of tumor treatment, and in particular relates to a device and a method for treating tumors. Background technique [0002] The methods currently used to treat tumors mainly include surgical resection, radiation therapy, chemotherapy, and hyperthermia. Due to the limitations of corresponding indications, contraindications, side effects and other factors, the efficacy of these methods on tumors is still not ideal. [0003] Pulse electrochemical therapy is a new technology for tumor treatment developed in the past 30 years, which was pioneered by Japanese scholar M.Okino in 1987. The treatment method is to give intravenous administration or intramuscular injection around the tumor tissue, give a certain dose of chemotherapy drugs (such as bleysin, cisplatin, etc.) Dose of square wave electrical pulse (peak value 1-2kV / cm, pulse width 100μs, frequency 1-4Hz, number of pulses 4-10) adjuvant therapy. Under norma...
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