Preparation method of 1-isopropyl-3-tertiary butyl thiocarbamide

A technology of tert-butylthiourea and isopropyl, which is applied in the field of preparation of pesticide intermediates, can solve problems such as high vapor pressure and difficult treatment of three wastes, and achieve the effects of low cost, reduced risk and safe operation

Active Publication Date: 2011-03-30
LIANYUNGANG JINDUN AGROCHEMICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Toluene is a precursor chemical, and the vapor pressure of these solvents is relatively high, so production accidents are prone to occur, and it also brings difficulties to the treatment of three wastes

Method used

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  • Preparation method of 1-isopropyl-3-tertiary butyl thiocarbamide
  • Preparation method of 1-isopropyl-3-tertiary butyl thiocarbamide
  • Preparation method of 1-isopropyl-3-tertiary butyl thiocarbamide

Examples

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Effect test

Embodiment 1

[0014] Example 1. The invention discloses a preparation method of 1-isopropyl-3-tert-butylthiourea. In the preparation process of 1-isopropyl-3-tert-butylthiourea, chlorobenzene is used as a solvent.

Embodiment 2

[0015] Example 2. In the preparation method described in Example 1, the specific steps are as follows: tert-butyl isothiocyanate is added in chlorobenzene, the weight ratio of tert-butyl isothiocyanate to chlorobenzene is 1:4, and stirred for 10 minutes; Cool to 0°C and add isopropylamine dropwise for 0.5 hours; the molar ratio of isopropylamine to tert-butyl isothiocyanate is 1:0.9; - A solution of isopropyl-3-tert-butylthiourea; after cooling to 0°C, centrifuge and dry to obtain 1-isopropyl-3-tert-butylthiourea.

Embodiment 3

[0016] Example 3. In the preparation method described in Example 1, the specific steps are as follows: tert-butyl isothiocyanate is added in chlorobenzene, the weight ratio of tert-butyl isothiocyanate to chlorobenzene is 1:8, and stirred for 40 minutes; Cool to 30°C, add isopropylamine dropwise for 2 hours; the molar ratio of isopropylamine to tert-butyl isothiocyanate is 1: 1.1; - A solution of isopropyl-3-tert-butylthiourea; after cooling to 20°C, centrifuge and dry to obtain 1-isopropyl-3-tert-butylthiourea.

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Abstract

The invention relates to a preparation method of 1-isopropyl-3-tertiary butyl thiocarbamide, which is characterized by using chlorobenzene as a solvent in the process of preparing the 1-isopropyl-3-tertiary butyl thiocarbamide. The method comprises the following concrete steps: adding tert-butyl isothiocyanate to the chlorobenzene and stirring; cooling, dropwise adding isopropylamine, and insulating and reacting after dropwise adding the isopropylamine to obtain the solution of the 1-isopropyl-3-tertiary butyl thiocarbamide; and after cooling, centrifuging and drying to obtain the 1-isopropyl-3-tertiary butyl thiocarbamide. The invention has safer and simpler technological operation, no three wastes and high yield, and is more environment-friendly and more suitable for industrial production.

Description

technical field [0001] The invention relates to a preparation method of a pesticide intermediate, in particular to a preparation method of 1-isopropyl-3-tert-butylthiourea. Background technique [0002] 1-isopropyl-3-tert-butylthiourea is the key intermediate for the preparation of buprofezin, the chemical name of buprofezin is 2-tert-butylimino-3-isopropyl-5-phenyl-1 ,3,5-thiadiazin-4-one is a thiadiazine insect growth regulator and belongs to insect molt inhibitor. By inhibiting the synthesis of chitin and interfering with metabolism, the pests cannot molt and metamorphosis normally and gradually die. It has the characteristics of high activity, high selectivity and long residual period. It is a chitin synthesis inhibitor of heterocyclic insects that does not kill adults, but can reduce oviposition and hinder egg hatching. Buprofezin is an agricultural insecticide with persistent larvicidal activity against Coleoptera, some Homoptera and Acarina. It can effectively con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C335/08
Inventor 王耀良石卫兵
Owner LIANYUNGANG JINDUN AGROCHEMICAL CO LTD
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