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New stomachic core coated tablet and preparation method thereof

A chip-packed and stomach-strengthening technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of inability to quickly relieve the pain of patients with symptoms, decrease in baicalin content, and prolong the onset time, etc. Low cost, extended shelf life, pain-relieving effect

Active Publication Date: 2011-04-06
CHENGDE TRADITIONAL CHINESE MEDICINE GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the existing drugs for the treatment of stomach diseases usually require a long disintegration time, thereby prolonging the onset time, and cannot relieve symptoms quickly to relieve the pain of the patient, and because the active ingredient baicalin in the tablet contains multiple phenolic Hydroxyl, which is weakly acidic, and the mother nucleus of baicalinin is easily hydrolyzed to form baicalein in a strong alkaline solution. Therefore, after being directly mixed with the alkaline substance sodium bicarbonate and compressed into tablets, it is inevitable to absorb the surrounding environment during storage. The moisture of baicalin will easily cause the hydrolysis of baicalin under alkaline conditions, resulting in a decrease in the content of baicalin, thereby reducing the efficacy

Method used

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  • New stomachic core coated tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Prepare Xinjian Stomach Pack Chips according to the following method:

[0023] Take 55g of Scutellaria baicalensis, 20g of 5% starch slurry, 5g of sodium carboxymethyl starch, 0.5g of sodium lauryl sulfate, make Scutellaria baicalensis into a fine powder, mix it with other raw materials and granulate it, and dry it at 100°C, then mix it with 0.5 g magnesium stearate is mixed and compressed, coated with a film coat (Tianjin Aileyi Company's Yishili), making the tablet core;

[0024] Add 8 times of weight of water to 40g of tangerine peel for extraction to obtain 0.8mL of volatile oil of tangerine peel, then add 6 times of weight of water to the extracted medicinal residues and continue to decoct for two hours, and the filtrates are combined and concentrated into 105g paste;

[0025] Take Atractylodes atractylodis 40g, rhubarb 15g, sodium bicarbonate 350g, starch 20g, make atractylodes atractylodes and rhubarb into fine powder, mix with sodium bicarbonate, starch and the ...

Embodiment 2

[0028] Prepare Xinjian Stomach Pack Chips according to the following method:

[0029] Get Scutellaria baicalensis 55g, rhubarb 15g, 5% starch slurry 25g, sodium carboxymethyl starch 5g, sodium lauryl sulfate 0.5g, make scutellaria baicalensis and rhubarb into fine powder, mix with other raw materials and granulate, and granulate at 100°C Dried, then mixed with 0.6g magnesium stearate and then pressed into tablets, coated with a film coat (Tianjin Aileyi Company Yishili), made tablet core;

[0030] Add 8 times the water of weight part in 40g tangerine peel and extract, obtain 0.8mL volatile oil of tangerine peel, add the water decoction of 6 times weight part in the dregs after extracting then, each 1 hour, concentrate after the filtrate merges into 105g paste;

[0031] Take 40g of Atractylodes atractylodis, 350g of sodium bicarbonate, and 19.2g of starch, make Atractylodes atractylodes into fine powder, mix them with sodium bicarbonate, starch and the paste obtained in the pr...

Embodiment 3

[0034] Prepare Xinjian Stomach Pack Chips according to the following method:

[0035] Add 8 times the water of weight part in 40g tangerine peel and extract, obtain 0.8mL volatile oil of tangerine peel, add the water decoction of 6 times weight part in the dregs after extracting then, each 1 hour, concentrate after the filtrate merges into 105g paste;

[0036] Take 55g of Scutellaria baicalensis, 15g of rhubarb, 40g of herb, 40g of 5% starch slurry, 5g of sodium carboxymethyl starch, and 0.5g of sodium lauryl sulfate. Sodium starch, sodium lauryl sulfate, and the paste obtained in the previous step were mixed and granulated, and dried at 100°C, then mixed with 1g magnesium stearate and pressed into tablets, coated with a film coat (Tianjin Aileyi Company) Easy to release Li), made the tablet core;

[0037] Take 350g of sodium bicarbonate, 20g of starch, and 135g of 5% starch slurry, mix and granulate, dry at 40°C and add tangerine peel volatile oil to obtain a coating layer;...

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Abstract

The invention discloses a new stomachic core coated tablet and a preparation method thereof. The new stomachic core coated tablet comprises a film coated tablet core and a coating layer coated on the tablet core, wherein the tablet core and the coating layer are formed by combining one of rhizoma atractylodis, rhubarb, radix scutellariae, dried orange peel, sodium bicarbonate and other addition agents; the tablet core and the coating layer are compressed into core coated tablets through a core coated tablet press. The new stomachic core coated tablet disclosed by the invention has the effects of clearing heat, drying damp, and relieving hyperacidity and stomach trouble, is used for curing liver and stomach hot and suffocating, such as acid regurgitation, gastric cavity, stuffy feeling, indigestion and the like, and has the characteristics of fast effect taking, long action time, high stability, simple preparation technique and low cost.

Description

technical field [0001] The invention relates to a medicament for treating stomach diseases and a preparation method thereof, more specifically, a Xinjian stomach bag chip and a preparation method thereof. Background technique [0002] Due to the accelerating pace of life and work in today's society, the gradual increase of various pressures, and bad living habits such as irregular eating habits, the incidence of stomach diseases is increasing. Under normal circumstances, gastric acid secretion is to digest food, and it is also the first line of defense to kill bacteria in the body, but improper stimulation can cause excessive gastric acid secretion, causing strong contraction and spasm of the stomach wall, causing pain, burning and other discomfort to the patient In severe cases, it even erodes the mucous membrane of the stomach and causes ulcers. If ulcers are soaked in gastric acid for a long time, they will easily deteriorate and increase the tendency of cancer. Therefo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61K9/30A61P1/00A61P1/04A61K33/00
Inventor 杨冬丽王春民刘井利董海荣郭金甲董晓强那海芬郑艳春刘刚
Owner CHENGDE TRADITIONAL CHINESE MEDICINE GROUP
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