Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Anti-infective catheters

An anti-infection and anti-infection agent technology, applied in the direction of catheter, tracheal intubation, biocide, etc., can solve disseminated infection, legacy medical care problems and other problems

Inactive Publication Date: 2011-04-06
ANGIOTECH INT AG (CH)
View PDF115 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

First, the device becomes a source of infection in the body, leading to localized or disseminated infection
Second, if an infection occurs, it cannot be treated with the antibiotics used in the utensil coating
The development of antibiotic-resistant microbial strains leaves significant healthcare concerns not only for the infected patient but also for the healthcare facility in which they occur

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anti-infective catheters
  • Anti-infective catheters
  • Anti-infective catheters

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0428] Manufacture of Coated Central Venous Catheters

[0429] By using VWR SPEC-WIPE saturated with 75 / 25 IPA / MEK The 7 wiper wiped and cleaned the CVC from the proximal end to the distal end of the CVC body. Catheters were dried at ambient temperature for a minimum of 60 minutes.

[0430] The conduits were then mounted on angle iron brackets used as coating jigs. Place the applicator cup on the conduit and install the angle iron bracket on the applicator. The coating solution prepared according to the present invention was added to the coating cup and the catheter was coated. During this procedure, the lumen of the catheter is purged of air to ensure that the lumen and ports are not entrapped with coating solution.

[0431] Take the coated catheter out of the coating machine, and dry it in a ventilated oven at 85±5°C for 20 minutes to remove residual solvents to a qualified level. The coated catheter was removed from the oven and allowed to cool. The coated catheters ...

Embodiment 2

[0436] Drug Elution from Coated Catheters

[0437] The in vitro elution profile of 5-FU from CVC coatings prepared as described in Example 1 was determined. Elution was performed by immersing a 4 cm portion of the coated catheter sample in 15 mL of phosphate buffered saline, pH 7.4 (PBS) at 37°C. Place the sample in a rotating device for stirring. Elution medium was sampled at selected times and analyzed by HPLC. Such as image 3 As shown, 5-FU gradually eluted from the catheter coating, releasing nearly 50% of the drug on the seventh day and 90% on the twenty-eighth day.

Embodiment 3

[0439] Stability of Coated Catheters

[0440] A stability study was performed using coated catheters manufactured according to Example 1 to determine the shelf life / expiration date of these catheters. Experimental evaluation of drug components includes drug identity, drug content, and in vitro elution. Evaluation of the coated polymers included visual inspection, dry adhesion and wet abrasion / wet peel tests.

[0441]Catheters were tested for stability using both real-time (25°C / 60% RH) and accelerated (40°C / 75% RH) conditions. Based on the analysis of the data, at 24 months at 25°C and 60% RH, with a 95% confidence level, (1) the total 5-FU content of the catheter is not expected to fall below 92.92% of the initial value, (2) The purity of the drug is expected to remain above 95.25%, (3) The defect rate in the dry adhesion and wet peel / wet abrasion tests of the coating is expected to be less than 5%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

Anti-infective catheters are provided. Such catheters comprise a composition that comprises a pyrimidine analog, polyurethane, and cellulose or a cellulose-derived polymer, for example, in form of a coating. In addition, anti-infective compositions and methods of making and using anti-infective catheters are provided.

Description

technical field [0001] The present invention relates generally to anti-infective compositions and devices and methods of making and using the same. Background technique [0002] Infection from medical implants is a major medical problem. For example, nosocomial infections develop in 5% of patients admitted to emergency care units. Nosocomial infections (hospital infections) are the eleventh leading cause of death in the United States and cost more than two billion dollars annually. Nosocomial infections are directly responsible for 19,000 deaths and affect more than 58,000 others each year in the United States. [0003] The four most common causes of nosocomial infections are: urinary tract infection (28%); surgical site infection (19%); respiratory tract infection (17%); and bloodstream infection (16% and increasing). A large percentage of these infections are associated with implanted medical implants such as Foley catheters (urinary tract infections), tracheal and trac...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61M25/00A61K31/717A61K31/74
CPCA61L2300/45A61M2025/0056A61M25/0017A61M16/04A61L29/16A61L29/085A01N43/54A61L2300/204A61M25/0045A61K31/74A61L2300/404
Inventor 乔伊·伊兰·佩里亚历山德拉·M·张伯伦斯科特·F·罗塞布罗夫
Owner ANGIOTECH INT AG (CH)
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com