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Human umbilical cord mesenchymal stem cell (HUMSC) anti-hepatic fibrosis injection and preparation method thereof

An anti-liver fibrosis and stromal cell technology, applied in the field of human umbilical cord mesenchymal stem cell anti-liver fibrosis injection and its preparation, achieving the effects of wide sources, no ethical restrictions, and high stability

Inactive Publication Date: 2011-11-16
中源协和生物细胞存储服务(天津)有限公司
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  • Human umbilical cord mesenchymal stem cell (HUMSC) anti-hepatic fibrosis injection and preparation method thereof
  • Human umbilical cord mesenchymal stem cell (HUMSC) anti-hepatic fibrosis injection and preparation method thereof
  • Human umbilical cord mesenchymal stem cell (HUMSC) anti-hepatic fibrosis injection and preparation method thereof

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[0021] In order to further explain the technical means and effects adopted by the present invention to achieve the predetermined purpose, the following is combined with the accompanying drawings and preferred embodiments to describe the human umbilical cord mesenchymal stem cell anti-hepatic fibrosis injection and its preparation method according to the present invention. , its specific implementation, structure, features and effects are described as follows.

[0022] The human umbilical cord mesenchymal stem cell anti-hepatic fibrosis injection provided by the present invention is composed of 10%-50% human serum albumin stock solution, 49.5%-89.5% Bomaili A solution, and 0.5% heparin calcium. The concentration of human serum albumin stock solution is 10%, and the concentration of human umbilical cord mesenchymal stem cells in the injection is 6×10 5 -7×10 5 pieces / ml. The injection of the embodiment of the present invention is composed of 20% human serum albumin stock solut...

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Abstract

The invention discloses a human umbilical cord mesenchymal stem cell (HUMSC) anti-hepatic fibrosis injection and a preparation method thereof. The injection is composed of 10%-50% of human albumin stock solution, 49.5%-89.5% of acetated Ringer's solution and 0.5% of heparin calcium, wherein, the concentration of the human albumin stock solution is 10%, and 1ml of the injection contains 6*10<5>-7*10<5> HUMSCs. The preparation method comprises the following steps: providing an MSC preserving fluid and pre-cooling the MSC preserving fluid for later use, wherein, the MSC preserving fluid comprises the human albumin stock solution, the Acetated Ringer's solution and the heparin calcium; providing the HUMSCs and adding the HUMSCs to the MSC preserving fluid; and adjusting the number of the HUMSCs added to the MSC preserving fluid to be 6*10<5>-7*10<5> HUMSCs / ml by means of re-suspending. The injection provided by the invention has the advantages of obvious curative effect and high stability, and is convenient in storage and transport and safe in use, thus being capable of bringing gospel to patients with hepatic fibrosis.

Description

[technical field] [0001] The invention relates to a preparation method of an injection, in particular to a human umbilical cord mesenchymal stem cell anti-hepatic fibrosis injection and a preparation method thereof. [Background technique] [0002] Hepatic fibrosis is a compensatory reaction in the tissue repair process secondary to liver inflammation or injury caused by various reasons. It is the result of pathological changes caused by excessive deposition of extracellular matrix in the liver. link. At present, liver lesions at this stage are reversible, but if they are not treated promptly and effectively, they will eventually lead to liver cirrhosis, upper gastrointestinal bleeding, liver ascites, liver cancer, and liver failure, which are one of the main causes of human death. First, reversing or delaying the process of liver fibrosis is an important link in the treatment of liver diseases. There are many causes of liver fibrosis, and liver fibrosis caused by viral hep...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/44C12N5/0775A61P1/16A61K35/28
Inventor 刘拥军朱德琳刘广洋徐萌谢姜
Owner 中源协和生物细胞存储服务(天津)有限公司
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