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Crystal form III of (S)-alpha, alpha-[(2-chlorphenyl)-(4,5,6,7-thiophane[3,2-c]pyridine-5-yl)-N'-(dimethyl)methylene] acethydrazide and preparation method thereof

A technology of tetrahydrothiophene and chlorophenyl, which is applied in the field of -α, can solve problems that do not involve the crystal form of the compound of formula I, etc.

Active Publication Date: 2012-05-30
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] However, the patent ZL200510016205.X does not involve the crystal form of the compound of formula I

Method used

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  • Crystal form III of (S)-alpha, alpha-[(2-chlorphenyl)-(4,5,6,7-thiophane[3,2-c]pyridine-5-yl)-N'-(dimethyl)methylene] acethydrazide and preparation method thereof
  • Crystal form III of (S)-alpha, alpha-[(2-chlorphenyl)-(4,5,6,7-thiophane[3,2-c]pyridine-5-yl)-N'-(dimethyl)methylene] acethydrazide and preparation method thereof
  • Crystal form III of (S)-alpha, alpha-[(2-chlorphenyl)-(4,5,6,7-thiophane[3,2-c]pyridine-5-yl)-N'-(dimethyl)methylene] acethydrazide and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Weigh 5.0 g of the compound of formula I, add 20 mL of acetonitrile-tetrahydrofuran mixture (volume ratio 65:35), heat to 35 ° C, stir and dissolve, keep warm for 4 hours, filter while it is hot, control the cooling rate to slowly cool to room temperature, place. A solid was precipitated, filtered, and dried in vacuum for about 24 hours to obtain a colorless crystalline powder.

Embodiment 2

[0054] Weigh 5.0 g of the compound of formula I, add 40 mL of acetonitrile-tetrahydrofuran mixture (volume ratio 70:30), heat to 45 ° C, stir and dissolve, keep warm for 8 hours, filter while hot, control the cooling rate to slowly cool to room temperature, place. A solid was precipitated, filtered, and dried in vacuum for about 24 hours to obtain a colorless crystalline powder.

Embodiment 3

[0056] Weigh 5.0 g of the compound of formula I, add 60 mL of acetonitrile-tetrahydrofuran mixture (volume ratio 80:20), heat to 60 ° C, stir and dissolve, keep warm for 12 hours, filter while hot, control the cooling rate to slowly cool to room temperature, place. A solid was precipitated, filtered, and dried in vacuum for about 24 hours to obtain a colorless crystalline powder.

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Abstract

The invention relates to a crystal form III of (S)-alpha, alpha-[(2-chlorphenyl)-(4,5,6,7-thiophane[3,2-c]pyridine-5-yl)-N'-(dimethyl)methylene] acethydrazide and a preparation method thereof, and also relates to a drug composition prepared from the new crystal form III and application thereof. The characteristics of the crystal form III are represented by powder X-ray diffraction data and melting point data.

Description

technical field [0001] The invention belongs to the field of antiplatelet aggregation drugs, more specifically, relates to (S)-α,α-[(2-chlorophenyl)-(4,5,6,7-tetrahydrothieno[3,2 -c] Crystal form III of pyridin-5-yl)]-N'-(dimethyl)methylidene)acetylhydrazide and its preparation method. Background technique [0002] Thrombosis can lead to acute myocardial infarction, stroke, pulmonary embolism and other diseases of the heart, brain, and pulmonary circulation, threatening human health and life, and is also a common complication in surgery and a factor of reocclusion after interventional angioplasty. Although thrombolytic therapy, interventional therapy and even surgical treatment carried out in recent years have made remarkable progress in the treatment of acute myocardial infarction and cerebral infarction, the success rate of patient rescue has been greatly improved, and the quality of life has also been significantly improved, but cardiovascular and cerebrovascular After a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D495/04A61K31/4365A61P7/02
Inventor 刘登科刘颖穆帅支爽龙丽陈旭白玫汤立达
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH