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Application of Ketanserin

A technology of ketanserin and drugs, applied in cardiovascular system diseases, drug combinations, etc., to achieve the effect of broadening the scope of application

Inactive Publication Date: 2012-08-22
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, at present, there is no report on the use of ketanserin for the prevention and treatment of endotoxic shock.

Method used

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  • Application of Ketanserin
  • Application of Ketanserin
  • Application of Ketanserin

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Experimental program
Comparison scheme
Effect test

Embodiment

[0013] The effect of embodiment ketanserin on endotoxic shock

[0014] Source and breed of mice: Kunming mice were obtained from Shanghai Slack Experimental Animal Co., Ltd.

[0015] The establishment of endotoxin shock model: the method of reference (Borovikova LV, Ivanova S, Zhang M, et al: Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000; 405: 458-462), intraperitoneal injection of endotoxin ( 30mg / kg, i.p.) induced endotoxin shock in mice to establish a model.

[0016] Administration: The mice were randomly divided into 5 groups, 21 in each group, which were respectively the control group without injection of ketanserin and the experimental group with intraperitoneal injection of different doses of ketanserin. Observe the 72-hour survival rate of endotoxic shock mice, the results are shown in Table 1, and the survival curve is as follows figure 1 .

[0017] Table 1 72-hour survival of each experimental group (n=21)

[0018...

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Abstract

The invention discloses the application of Ketanserin in preparation of medicine for preventing or treating endotoxic shock, thus expanding the application scope and providing a new way for preventing and treating the endotoxic shock.

Description

technical field [0001] The invention relates to a new application of ketanserin in the field of medicine. Background technique [0002] Ketanserin is a relatively specific serotonin 2A receptor antagonist developed in recent years, and its chemical name is 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl] Ethyl]-2,4[1H,3H]-quinazoledione, the structural formula is as shown in formula I: [0003] [0004] Formula I [0005] At present, ketanserin is mainly used to treat hypertension clinically, and its mechanism of action is mainly related to its 5HT-2A receptor blocking effect and adrenal α1 receptor blocking effect (Ketanserin in parenteral treatment of acute essential hypertension: a dose-response curve. Milei J, Lemns J, Schiavone M, et al. J Cardiovasc Pharmacol 1987; 10(suppl 3): 96-100). However, there is no report on the use of ketanserin for the prevention and treatment of endotoxic shock. Contents of the invention [0006] The technical problem to be solved by the p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/517A61P9/00
Inventor 苏定冯刘冲张谷芳沈甫明
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY