Hypocrella bambusae medicinal material and quality control method of preparation thereof

A quality control method, bamboo red fungus technology, applied in the direction of antibacterial drugs, material separation, analysis of materials, etc., to achieve the effect of comprehensive comparison, objective and reliable identification results, and short time required

Active Publication Date: 2011-04-27
YUNNAN PHYTOPHARML
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the current standards of bamboo red fungus medicinal materials, as well as pharmaceutical preparations containing bamboo red fungus, daily chemical products, etc., there is no thin-layer chromatography identification method for its active ingredients hypocregia A, B, and C as indicators, and a new method is invented. A method that can quickly and accurately identify bamboo red fungus medicinal materials, pharmaceutical preparations containing bamboo red fungus, and daily chemical products has practical application value

Method used

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  • Hypocrella bambusae medicinal material and quality control method of preparation thereof
  • Hypocrella bambusae medicinal material and quality control method of preparation thereof
  • Hypocrella bambusae medicinal material and quality control method of preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: the identification of bamboo red fungus medical material

[0032]The bamboo red fungus commercial medicinal material is pulverized, 0.5g of the powder is taken, 10ml of acetone is added, ultrasonic treatment is performed for 30 minutes, and filtration is used as the test solution. Another reference substance of hypocrellin A, B, and C was dissolved in acetone to make a solution with a concentration of 1 mg / ml as the reference solution. Take 4 μl each of the reference substance solution and the test solution, and place them on the same silica gel G thin-layer plate, using dichloromethane-toluene-ethyl acetate-butanone (40:5:1:1) as the developing solvent, Unroll in the upper row, remove, and let dry. The chromatogram is inspected under sunlight. In the chromatogram of the test product, red spots of the same color appear on the position corresponding to the chromatogram of the reference substance, and red fluorescent spots of the same color appear when view...

Embodiment 2

[0033] Embodiment 2: the identification of bamboo red fungus medical material

[0034] The reference substance solution and the preparation of the test substance solution, sample application, development, and color development are the same as in Example 1, the only difference is that dichloromethane-toluene-ethyl acetate-butanone (40:5:0.5:0.5) is used as the developer . According to the identification results of thin-layer chromatography, it can be clearly determined that the commercial medicinal material is bamboo red fungus medicinal material.

Embodiment 3

[0035] Embodiment 3: the identification of bamboo red fungus medical material

[0036] The reference substance solution and the preparation of the test substance solution, sample application, development, and color development are the same as in Example 1, the only difference is that dichloromethane-toluene-ethyl acetate-butanone (40:10:1.5:1.5) is used as the developer . According to the identification results of thin-layer chromatography, it can be clearly determined that the commercial medicinal material is bamboo red fungus medicinal material.

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Abstract

The invention provides a hypocrella bambusae medicinal material and a quality control method of a preparation thereof. The method is characterized in that: hypocrellin A, hypocrellin B and hypocrellin C serve as reference substances and are identified by thin-layer chromatography method to realize the quality control. In the thin-layer chromatography, silica gel G is taken as an adsorbent and dichloromethane-toluene-ethyl acetate-butanone is taken as a developer in the ratio of 40 to 5 to 1 to 1. In the method, the judgment indicator is visual and definite, and the identification result is objective and reliable. The method has the advantages of comprehensive contrast, high specificity and high accuracy, and is used for identifying the hypocrella bambusae medicinal material, and a medicinal preparation and a daily health product prepared from the hypocrella bambusae medicinal material serving as a raw material.

Description

technical field [0001] The invention relates to bamboo red fungus medicinal material and a quality control method of a pharmaceutical preparation containing bamboo red fungus medicinal material, belonging to the technical field of traditional Chinese medicine quality control. Background technique [0002] Bamboo red fungus is the dry sub-seat of Hypocrella Bambusae (B.et Br.) Sacc., a fungus of the Hypocreataceae family. It is distributed in Yunnan, Sichuan, Tibet and other places. The medicinal materials are mainly produced in Dali, Northwest Yunnan. Lijiang City, Diqing Prefecture. This product is a characteristic ethnic medicine of Yunnan, and is widely used in ethnic medicines of the Naxi, Bai, Yi and other ethnic groups in northwestern Yunnan. (The first volume of "Yunnan Traditional Chinese Medicine", the first edition of Yunnan Science and Technology Press in 1990, pages 268-269; the first volume of "Chinese Materia Medica", the first edition of Shanghai Science and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/06A61K9/06G01N30/90A61P15/00A61P17/02A61P31/04
Inventor 饶高雄周艳林潘韬文李俊
Owner YUNNAN PHYTOPHARML
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