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Method for preparing rupestonic aid

A technology of artemisinic acid and acid alcohol, which is applied in the field of extraction and purification of artemisinic acid, can solve the problems of environmental pollution, solvent residue, waste of energy, etc., and achieve the effects of high product purity, high raw material utilization rate, and improved extraction rate

Inactive Publication Date: 2011-05-04
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chinese patent (Application No. 200810072934.0) "Using high-speed counter-current chromatography to purify the method of artemisinic acid and golden waist element B", using a mixed solvent composed of n-hexane, ethyl acetate, methanol and water as the high-speed counter-current chromatographic separation solvent system, This method requires a large amount of harmful chemical solvents, which not only wastes precious energy, but also causes relatively serious environmental pollution, and there are inevitably solvent residues.
However, there is no report on the extraction of artemisinic acid with supercritical fluid

Method used

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  • Method for preparing rupestonic aid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take a stalk of Artemisia medicinal material and crush it into 60 meshes, take 5 kg and add 110ml of 75% acidic ethanol (containing 2% hydrochloric acid) to microwave intermittent radiation for 120s, the microwave power is 400W, keep the extraction environment below 60°C, repeat the same method twice, and extract twice Mix the liquid and put it in a reaction tank to concentrate and dry, put the crude extract into the extraction tower, seal it, increase the extraction temperature to 38°C, adjust the temperature of the separation tower to 56°C, extract the pressure to 36MPa, analyze the pressure to 6MPa, CO 2 The gas is released from the steel cylinder, cooled to 0-5°C in the liquefaction tank after passing through the gas purifier, and liquefied. into the storage tank with a high-pressure metering pump to CO 2 and 520ml ethanol into the preheater, through the preheater to the specified temperature and pressure, the ethanol is entrained from the lower part of the extracti...

Embodiment 2

[0030] Take a stalk of Artemisia medicinal material and crush it into 40 meshes, take 5kg and add 10ml of 80% acidic ethanol (containing 5% tartaric acid) into microwave intermittent radiation for 200s, the microwave power is 200W, keep the extraction environment below 60°C, repeat the same method twice, and extract the two times Mix the liquid and put it in a reaction tank to concentrate and dry, put the crude extract into the extraction tower, seal it, raise the extraction temperature to 36°C, adjust the temperature of the separation tower to 55°C, extract the pressure to 33MPa, analyze the pressure to 4MPa, CO 2 The gas is released from the steel cylinder, cooled to 0-5°C in the liquefaction tank after passing through the gas purifier, and liquefied. into the storage tank with a high-pressure metering pump to CO 2and 500ml of ethanol are sent to the preheater, through the preheater to the specified temperature and pressure, the ethanol is entrained from the lower part of th...

Embodiment 3

[0032] Take a stalk of Artemisia medicinal material and crush it into 100 meshes, take 10kg and add 200ml of 90% acidic ethanol (containing 3% sulfuric acid) to microwave intermittent radiation for 180s, the microwave power is 700W, keep the extraction environment below 60°C, repeat the same method twice, and extract twice Mix the liquid and put it in a reaction tank to concentrate and dry, put the crude extract into the extraction tower, seal it, increase the extraction temperature to 47°C, adjust the temperature of the separation tower to 58°C, extract the pressure to 35MPa, analyze the pressure to 7MPa, CO 2 The gas is released from the steel cylinder, cooled to 0-5°C in the liquefaction tank after passing through the gas purifier, and liquefied. into the storage tank with a high-pressure metering pump to CO 2 and 1000ml ethanol into the preheater, through the preheater to the specified temperature and pressure, the ethanol is entrained from the lower part of the extraction...

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Abstract

The invention provides a method for preparing rupestonic aid. The method for preparing the rupestonic aid comprises the following steps of: crushing dried whole Artemisia rupestris L; performing microwave extraction and filter pressing, and drying; extracting the dried object again, separating and gathering, and purifying; and crystallizing and drying to obtain a finished product. High-purity rupestonic aid is obtained through supercritical fluid extraction and column chromatography separation and purification, and the method has the advantages of high yield, low operating cost, environmental-friendliness, and the like.

Description

Technical field: [0001] The invention belongs to the technical field of extraction and purification of artemisinic acid, and relates to a method for extracting and preparing high-purity artemisinic acid by using supercritical fluid extraction and column chromatography enrichment and purification technology. Background technique: [0002] Artemisia argyi is the whole herb of Artemisia rupestris L. of Compositae, also known as Artemisia rupestris L. Produced in the Tianshan Mountains and Altai Mountains in the Xinjiang Uygur Autonomous Region, it is a commonly used medicine for the Uygur people. It has the effects of dispelling wind and relieving the exterior, invigorating the stomach and eliminating accumulation, promoting blood circulation and detoxification. Snakebite, hives. Modern pharmacological studies have shown that it has the functions of inhibiting smooth muscle contraction, anti-tumor, eliminating freedom, anti-allergic reaction and protecting liver. Compound med...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C59/82C07C51/42
CPCY02P20/54
Inventor 刘东锋郭琴杨成东
Owner NANJING ZELANG MEDICAL TECH
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