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Medicinal use of nalmefene hydrochloride

A technology of nalmefene hydrochloride and drugs, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, drug combinations, etc., to achieve the effects of reducing platelet aggregation rate, improving lipid metabolism, and improving prognosis

Active Publication Date: 2011-05-11
ZHUHAI TONGYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But the application of nalmefene hydrochloride injection in the treatment of fatty liver has not been reported

Method used

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  • Medicinal use of nalmefene hydrochloride

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Embodiment Construction

[0011] The present invention is further illustrated by the following examples

[0012] The present invention selects nalmefene hydrochloride injection as an anti-fatty liver drug, and explores the influence of nalmefene hydrochloride injection on fatty liver. Aim to choose a drug with strong anti-fatty liver effect.

[0013] Materials and Methods

[0014] 1. Experimental materials:

[0015] 1.1 Animals

[0016] Experimental animals: Wistar rats, clean grade, animal certificate number: SCXK (Sichuan) 2009-16. Body weight 200±20g, half male and half male, provided by the Institute of Experimental Animals, Sichuan Academy of Medical Sciences.

[0017] The above-mentioned animals were all raised in the SPF-level feeding room of the Experimental Animal Center of Chengdu University of Traditional Chinese Medicine in Sichuan. During the experiment, they had free access to water and food. The indoor temperature was controlled at 22-24°C, and the ventilation and humidity were good...

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Abstract

The invention relates to medicinal use of nalmefene hydrochloride. The nalmefene hydrochloride can improve lipid metabolism and improve prognosis of a fatty liver patient by reducing the platelet aggregation rate, improving the liver function state and resisting oxidation. The nalmefene hydrochloride can serve as a medicine for resisting human / animal fatty liver.

Description

technical field [0001] The invention relates to the medical application of nalmefene hydrochloride. Background technique [0002] Fatty liver (FL) is a common clinical disease. With the changes in people's diet structure and lifestyle, the incidence of fatty liver has increased significantly, and it has increasingly become a focus of attention and research in the medical field. A large number of studies have shown that most patients with fatty liver have microcirculation disorders, and the platelet aggregation rate is significantly increased. [0003] Nalmefene Hydrochloride Injection is indicated for complete or partial reversal of the effects of opioids, including respiratory depression caused by natural or synthetic opioids. For the treatment of known or suspected opioid overdose. However, the application of nalmefene hydrochloride injection in the treatment of fatty liver has not been reported. [0004] The applicant unexpectedly found that nalmefene hydrochloride in...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61P1/16
Inventor 黄毅彭国强张颀黄伟熊骏宇李润宝
Owner ZHUHAI TONGYUAN PHARMA CO LTD
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