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Stable complex vitamin composite and preparation method thereof

A technology of complex vitamins and vitamins, which is applied in the direction of drug combinations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as unresolved product stability issues

Active Publication Date: 2011-05-25
西藏中卫诚康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although CN1879648 discloses a kind of freeze-dried powder injection containing 13 kinds of vitamins with Tween 80 as solubilizing agent, the stability problem of its product is still unsolved

Method used

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  • Stable complex vitamin composite and preparation method thereof
  • Stable complex vitamin composite and preparation method thereof
  • Stable complex vitamin composite and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] (1) In a light-proof operation room, weigh vitamin A palmitate, racemic α-tocopherol, and vitamin D 3 , added to polysorbate 80, charged with nitrogen, stirred to dissolve, added with water for injection, stirred, and placed for later use.

[0103] (2) Take folic acid and biotin, add appropriate amount of sodium hydroxide solution to dissolve, set aside.

[0104] (3) Take vitamin C, nicotinamide, cocarboxylase tetrahydrate, vitamin B 6 , dexpanthenol, riboflavin sodium phosphate, vitamin B 12 , glycine, add water for injection and stir to dissolve, adjust the pH to 5.5-6.5 with 10% sodium hydroxide, and set aside.

[0105] (4) Mix the above (1), (2), and (3) evenly, add 0.05% activated carbon, stir for 30 minutes, filter, add water for injection to the full amount, measure the intermediate content and pH value, fine filter, and fill.

[0106] (5) The sample is freeze-dried to obtain.

Embodiment 2

[0108] Except replacing glycine with mannitol, it was prepared as in Example 1, and it was obtained.

Embodiment 3

[0110] (1) In a light-proof operation room, weigh vitamin A palmitate, racemic α-tocopherol, and vitamin D 3 , added to polysorbate 80, charged with nitrogen, stirred to dissolve, added with water for injection, stirred, and placed for later use.

[0111] (2) Take folic acid and biotin, add appropriate amount of sodium hydroxide solution to dissolve, set aside.

[0112] (3) Take dextran 40, add 80°C water and stir to dissolve, cool, add vitamin C, nicotinamide, cocarboxylase tetrahydrate, vitamin B 6 , dexpanthenol, riboflavin sodium phosphate, vitamin B 12 , add water for injection and stir to dissolve, adjust the pH to 5.5-6.5 with 10% sodium hydroxide, and set aside.

[0113] (4) Mix the above (1), (2), and (3) evenly, add 0.05% activated carbon, stir for 30 minutes, filter, add water for injection to the full amount, measure the intermediate content and pH value, fine filter, and fill.

[0114] (5) The sample is freeze-dried to obtain.

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PUM

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Abstract

The invention relates to an aqueous solution for preparing a stable complex vitamin composite, a complex vitamin composite injection and a preparation method thereof. The composite is prepared from 11 vitamins, or analogs thereof, racemization alpha-tocopherol, polysorbate and medically acceptable auxiliary materials by the freeze drying technology, wherein 11 vitamins comprises vitamin A palmitate, vitamin D3, vitamin C, cocarboxylase tetrahydrate, riboflavin sodium phosphate, vitamin B6, vitamin B12, folic acid, dexpanthenol, biotin and nicotinamide. Compared with the prior art, the composite has better stability.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to an aqueous solution for preparing a stable multivitamin composition, a multivitamin composition injection and a preparation method thereof. technical background [0002] Parenteral nutrition plays an important supporting role in the treatment of diseases, and is widely used in congenital digestive tract malformations, moderate to severe malnutrition, digestive tract diseases (severe diarrhea, necrotizing enterocolitis, early short bowel syndrome, intestinal Obstruction, intestinal fistula, necrotizing pancreatitis), critically ill newborns who cannot eat normally, severe gastrointestinal reactions caused by radiotherapy and chemotherapy, severe infection, major surgery, trauma, burns, etc. Vitamins are a kind of trace organic substances necessary to maintain human life activities. Generally, they cannot be synthesized by their own assimilation in the human b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/714A61K31/675A61K31/593A61K31/519A61K31/455A61K31/4415A61K31/4188A61K31/375A61K31/355A61K31/23A61K31/164A61K47/34A61P3/02A61K47/26
Inventor 胡军谷景斌刘烽张勇
Owner 西藏中卫诚康药业有限公司
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