Method for separating ginkgolide B from ginkgolide mixture

A technology of ginkgolides and mixtures, which is applied in the field of chemical engineering, can solve the problems of large solvent consumption, high equipment requirements, and large equipment investment, and achieve the effects of low cost, low consumption, and high production capacity

Inactive Publication Date: 2012-11-07
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Compared with column chromatography, this method has a higher yield, and the simulated moving bed process is a continuous process, but this method has higher requirements for equipment, and the equipment investment is large, and the simulated moving bed is used as a chromatographic operation process, and the processing capacity is small. Solvent consumption is high

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  • Method for separating ginkgolide B from ginkgolide mixture

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Commercially available ginkgolide mixture (wherein the percentage by weight of ginkgolide A, ginkgolide B, ginkgolide C is respectively 60%, 26% and 10%) and ethyl acetate is made into 20 g / liter stock solution , with N-ethylpyridinium bromide ([EPy]Br)-water mixed solvent as extractant ([EPy]Br weight fraction is 70%), with ethyl acetate as detergent, extractant, detergent, raw material solution The flow ratio of the three is 3:2.7:1. Fractional extraction is carried out in a fractional distillation extraction device at 40°C. The fractional distillation extraction is divided into an extraction section and a washing section. The last stage of the extraction section enters the fractionation extraction system, the detergent enters the fractionation extraction system from the first stage of the washing section, and the raw material liquid is combined into the extraction section at the last stage of the washing section, and the extraction phase and the washing phase are subj...

Embodiment 2

[0044] The commercially available ginkgolide mixture (wherein the total weight percentage of ginkgolide A, ginkgolide B, and ginkgolide C is 96%) and butyl acetate is made into a stock solution of 0.5 g / liter, and 1-butyl -3-Dimethylimidazolium tetrafluoroborate ionic liquid ([BMIm][BF 4 ]) as the extractant, with butyl acetate as the detergent, the flow ratio of the extractant, the detergent, and the raw material liquid is 2: 4.2: 1, and the fractionation extraction is carried out in a fractionation extraction device at 20°C, and the fractionation extraction is divided into The extraction section and the washing section, the extractant enters the fractionation extraction system from the first stage of the extraction section, the raw material liquid enters the fractionation extraction system from the last stage of the extraction section, and the detergent enters the fractionation extraction system from the first stage of the washing section. The last stage merges the raw mater...

Embodiment 3

[0046] Ginkgo biloba extract is subjected to steps such as general extraction, precipitation, evaporation solvent, and the total weight percentage that separates and obtains ginkgolide A, ginkgolide B, ginkgolide C is the solid of 42%, and the solid that obtains is mixed with n-butyl Alcohol is made into the stock solution of 100 g / liter, with tributylammonium chloride ([HNBu 3 ]Cl)-water mixed solvent is the extractant ([HNBu 3 ] Cl weight fraction is 95%) as extractant, with n-butanol as detergent, the flow ratio of extractant, detergent, raw material liquid three is 13: 1.7: 1, carries out fractionation in fractionation extraction device under 70 ℃ Extraction, fractional distillation extraction is divided into extraction section and washing section, the extractant enters the fractionation extraction system from the first stage of the extraction section, the raw material liquid enters the fractionation extraction system from the last stage of the extraction section, and the ...

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Abstract

The invention discloses a method for separating ginkgolide B from a ginkgolide mixture. The method comprises the following steps: by using an ionic liquid or a binary mixed solvent composed of ionic liquid and water as the extracting agent, and efficiently separating ginkgolide B from a mixture, which contains ginkgolide A, ginkgolide B, ginkgolide C and other ginkgolide homologues, through a fractional extraction process. The method has the advantages that the method has high separation efficiency, low solvent consumption, high safety, environmental protection and the like and is suitable for industrial production, etc.

Description

technical field [0001] The invention relates to a method for separating ginkgolide B, which belongs to the technical field of chemical engineering, in particular to a method for separating ginkgolide B from a mixture of ginkgolides. Background technique [0002] Ginkgolide is a kind of main active ingredient in Ginkgo biloba. It is a strong platelet-activating factor (platelet-activating factor, PAF) receptor antagonist. , Antibacterial and anti-inflammatory, anti-tumor, anti-rejection in organ transplantation and other curative effects. Ginkgolide has a twelve-carbon skeleton structure and is divided into ginkgolide A (ginkgolide A, GA), ginkgolide B (ginkgolide B, GB), ginkgolide C (ginkgolide C, GC) according to different substituents. Ginkgolide M (ginkgolide M, GM) and ginkgolide J (ginkgolide J, GJ), in addition to bilobalide (bilobalide, BB). The activity of ginkgolides is closely related to the chemical structure, among which ginkgolide B has the strongest antagoni...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/22
Inventor 邢华斌曹义风杨启炜苏宝根杨亦文苏云张芮菡倪晓蕾任其龙
Owner ZHEJIANG UNIV
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