Pharmaceutical composition containing medicinal calcium salt for early preventing colorectal adenoma or colorectal cancer
A colorectal adenoma and composition technology, which is applied in the direction of drug combinations, medical preparations containing active ingredients, active ingredients of phosphorus compounds, etc., can solve problems such as unsatisfactory effects, achieve inhibition of tumor cell growth, good preventive effect, and inhibit The effect of malignant transformation
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Embodiment 1
[0028] Example 1 Animal experiment
[0029] 352 S-ICR mice (SCXK (Shanghai) 2003-0003), clean grade, female, outbred, weighing 18-20 g were purchased from the Songjiang Experimental Animal Base of the Chinese Academy of Sciences, and were randomly divided into 16 groups with 22 animals in each group. The experiment was started after one week of feeding (0week).
[0030] The specific grouping, timing and method of administration are as follows:
[0031] 1) Sodium n-butyrate effect: Concentration of 1.5%, give drinking water continuously every day. Late intervention was given intervention drugs from the 13th week (13-24week); early full intervention was started from the 1st week (1-24week).
[0032] 2) Caltrate (purchased from Wyeth-Baigong Pharmaceutical Co., Ltd., USA) Function: 1.82mg / piece (containing vitamin D3 0.38iu), drink continuously every day. Late intervention was given intervention drugs from the 13th week (13-24week); early full intervention was started from the...
Embodiment 2
[0041] Example 2 Agilent expression profile chip analysis of tissue samples
[0042] The expression profile chip used in this example is from Agilent Technologies Co., Ltd. For specific experimental methods, refer to the experimental steps of Agilent Corporation:
[0043] www.agilent.com / chem / dnamanuals-protocols .
[0044]1 Quality control: TRIzol (Invitrogen) was used to extract total RNA, RNasey Mini kit (Qiagen p / n 74104) was used to wash total RNA, Quick Amp labeling kit, onecolor (Agilent p / n 5190-0442) was used to label, RNasey Mini kit (Qiagen p / n74104) to purify labeled RNA, NanoDrop ND-1000 for quality detection, and then hybridized with a whole genome oligo microarray (Agilent Technologies, Palo Alto, CA, USA) purchased from Agilent, and operated according to the recommended procedures : After hybridization and washing, use Agilent microarray scanner (Agilent p / n G2565BA) to scan the chip, and use Agilent Feature Extraction Software (version 10.5.1.1) for image a...
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