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Pharmaceutical composition containing medicinal calcium salt for early preventing colorectal adenoma or colorectal cancer

A colorectal adenoma and composition technology, which is applied in the direction of drug combinations, medical preparations containing active ingredients, active ingredients of phosphorus compounds, etc., can solve problems such as unsatisfactory effects, achieve inhibition of tumor cell growth, good preventive effect, and inhibit The effect of malignant transformation

Inactive Publication Date: 2012-02-15
RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to provide a pharmaceutical composition for the early prevention of colorectal adenoma or colorectal cancer containing medicinal calcium salt, said pharmaceutical composition for the early prevention of colorectal adenoma or colorectal cancer containing medicinal calcium salt To solve the unsatisfactory technical problem of the effect of the drugs used for early prevention of colorectal adenoma and colorectal cancer in the prior art

Method used

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  • Pharmaceutical composition containing medicinal calcium salt for early preventing colorectal adenoma or colorectal cancer
  • Pharmaceutical composition containing medicinal calcium salt for early preventing colorectal adenoma or colorectal cancer
  • Pharmaceutical composition containing medicinal calcium salt for early preventing colorectal adenoma or colorectal cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Animal experiment

[0029] 352 S-ICR mice (SCXK (Shanghai) 2003-0003), clean grade, female, outbred, weighing 18-20 g were purchased from the Songjiang Experimental Animal Base of the Chinese Academy of Sciences, and were randomly divided into 16 groups with 22 animals in each group. The experiment was started after one week of feeding (0week).

[0030] The specific grouping, timing and method of administration are as follows:

[0031] 1) Sodium n-butyrate effect: Concentration of 1.5%, give drinking water continuously every day. Late intervention was given intervention drugs from the 13th week (13-24week); early full intervention was started from the 1st week (1-24week).

[0032] 2) Caltrate (purchased from Wyeth-Baigong Pharmaceutical Co., Ltd., USA) Function: 1.82mg / piece (containing vitamin D3 0.38iu), drink continuously every day. Late intervention was given intervention drugs from the 13th week (13-24week); early full intervention was started from the...

Embodiment 2

[0041] Example 2 Agilent expression profile chip analysis of tissue samples

[0042] The expression profile chip used in this example is from Agilent Technologies Co., Ltd. For specific experimental methods, refer to the experimental steps of Agilent Corporation:

[0043] www.agilent.com / chem / dnamanuals-protocols .

[0044]1 Quality control: TRIzol (Invitrogen) was used to extract total RNA, RNasey Mini kit (Qiagen p / n 74104) was used to wash total RNA, Quick Amp labeling kit, onecolor (Agilent p / n 5190-0442) was used to label, RNasey Mini kit (Qiagen p / n74104) to purify labeled RNA, NanoDrop ND-1000 for quality detection, and then hybridized with a whole genome oligo microarray (Agilent Technologies, Palo Alto, CA, USA) purchased from Agilent, and operated according to the recommended procedures : After hybridization and washing, use Agilent microarray scanner (Agilent p / n G2565BA) to scan the chip, and use Agilent Feature Extraction Software (version 10.5.1.1) for image a...

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Abstract

The invention discloses a pharmaceutical composition containing medicinal calcium salt for early preventing colorectal adenoma or colorectal cancer. The pharmaceutical composition contains sodium butyrate and medicinal calcium salt, wherein the mass ratio of the sodium butyrate to elemental calcium in the pharmaceutical composition is (2.47-4.95):1. The pharmaceutical composition disclosed by theinvention can reduce cancer genes related to the colorectal cancer and can increase related cancer suppressor genes and signal passages to suppress colorectal cancer cell proliferation and migration capabilities and retard cell growth cycle, thereby achieving the purposes of suppressing the occurrence of the colorectal cancer, lowering the incidence rate of the colorectal cancer of mice, and reducing the tumor volume.

Description

Technical field: [0001] The present invention relates to the field of medicinal chemistry, in particular to a pharmaceutical composition, especially a pharmaceutical composition for early prevention of colorectal adenoma or colorectal cancer containing medicinal calcium salt. Background technique: [0002] Colorectal cancer is currently one of the three most common cancers in the world. In my country, with the accelerated pace of life and Westernized lifestyle, the occurrence and progression of colorectal cancer is showing a trend of increasing year by year. The occurrence of colorectal cancer is related to genetic variation and epigenetic abnormality. Although epidemiological surveys have shown that pteroylglutamic acid (PGA), sodium butyrate (Sodium butyrate), and vitamin D have certain preventive effects on colorectal cancer, the results of recent studies have been inconsistent. Past research results suggest that it may be related to the basal level of the above-mentione...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/19A61K31/593A61K31/191A61K31/194A61K33/10A61K33/08A61K33/42A61K38/14A61P35/00A61P1/00
Inventor 房静远陈慧敏王吉林林艳伟
Owner RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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