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Progesterone preparation composite and preparation method thereof

A progesterone and composition technology, applied in the field of medicine, can solve the problems of many adverse reactions, high bioavailability, and few adverse reactions, and achieve the effects of improving bioavailability, high bioavailability, and few adverse reactions

Active Publication Date: 2011-06-15
ZHEJIANG ASEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to propose a progesterone preparation composition with a high dissolution rate and a preparation method thereof in order to realize the dosage Small size, high dissolution rate, high bioavailability and few adverse reactions

Method used

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  • Progesterone preparation composite and preparation method thereof
  • Progesterone preparation composite and preparation method thereof
  • Progesterone preparation composite and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take by weighing 2 g of progesterone micropowder, 8 g of soybean lecithin and 92 g of soybean oil, mix and shake the progesterone micropowder, soybean lecithin and soybean oil that have been weighed, and carry out ultrasonic dissolution to obtain progesterone oil solution; use a soft mode capsule manufacturing machine , The obtained progesterone oil solution is evenly filled in 1000 soft capsules to prepare progesterone capsules.

Embodiment 2

[0035] Take by weighing 5 g of progesterone microparticles, 30 g of beeswax, 110 g of rapeseed oil and 60 g of Zanthoxylum bungeanum oil, mix and shake well the progesterone microparticles, soybean lecithin and rapeseed oil, and carry out ultrasonic dissolution to obtain progesterone oil solution; Model capsule manufacturing machine, the obtained progesterone oil solution is filled in 1000 soft capsules on average, makes progesterone capsules.

Embodiment 3

[0037] Weigh 10g of progesterone micropowder, 100g of egg yolk lecithin and 400g of corn oil, mix and shake the weighed progesterone micropowder, egg yolk lecithin and corn oil, and carry out ultrasonic dissolution to obtain progesterone oil solution; use a soft mode capsule manufacturing machine , The obtained progesterone oil solution is evenly filled in 1000 soft capsules to prepare progesterone capsules.

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Abstract

The invention discloses a progesterone preparation composite and a preparation method thereof, belonging to the field of chemical medicine preparations. The progesterone preparation composite comprises a progesterone oil solution containing substance, the progesterone oil solution containing substance is prepared from the following components by every 1000 progesterone preparation composites: 2-30 grams of progesterone, 75-1000 grams of nonpolar solvents and 0-180 grams of solubilizers, wherein the nonpolar solvent is vegetable oil or / and animal oil; and the solubilizer is lecithin or / and beewax. The reached progesterone preparation composite can be used for oral administration, is 10 times higher than a commercial progesterone capsule in dissolution rate and bioavailability, has the advantages of small taking dosage, high bioavailability, little adverse reaction, and the like and can be used for various diseases or symptoms, i.e. threatened abortion, habitual abortion, artificial insemination, sterility, premenstrual tension syndromes, anovulatory dysfunctional uterine bleeding, anovulatory amenorrhoea, endometriosis, climacteric syndromes, and the like which are caused by insufficient progestational hormones or corpus luteum functions.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a progesterone preparation composition with high dissolution rate and a preparation method thereof. Background technique [0002] Progesterone (English name is progesterone, chemical name is pregn-4-ene-3,20-dione) is a natural progesterone, which has the general effect of progesterone, and is widely used in the treatment of threatened abortion, habitual abortion, artificial Fertilization, infertility, premenstrual tension syndrome, anovulatory DUB, anovulatory amenorrhea, endometrial hyperplasia, endometrial adenocarcinoma, endometriosis, and menopausal syndrome A disease or condition caused by a deficiency. [0003] Progesterone is readily soluble in non-polar solvents and practically insoluble in water. Existing progesterone preparations include tablets and capsules, but because they are poorly absorbed in the stomach after oral administration and are easily metabolized and inactivat...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K9/20A61K31/57A61K47/44A61K47/42A61K47/24A61K47/46A61P15/06A61P15/08A61P15/12A61P15/00
CPCA61K31/57A61K47/44A61K35/644A61K9/08A61K35/64A61K9/4875A61P5/34A61P15/00A61P15/06A61P15/08A61P15/12A61K2300/00
Inventor 邓金明吴海英
Owner ZHEJIANG ASEN PHARMA
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