Pioglitazone hydrochloride chewable tablets and preparation method thereof

A technology of pioglitazone hydrochloride and chewable tablets, applied in the field of medicine, can solve problems such as single dosage form, and achieve the effects of good compliance, simple process and fast absorption by the human body

Inactive Publication Date: 2011-06-29
蒋明高
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the shortcoming of single oral dosage form of pioglitazone hydrochloride in the prior art, improve the bioavailability of insoluble drugs, reduce the toxic and side effects of drugs, and make patients have more dosage form options, it is the purpose of the present invention to develop pioglitazone hydrochloride chewable tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1) The prescription composition of pioglitazone hydrochloride chewable tablets is as follows, every 1000 pioglitazone hydrochloride chewable tablets contain:

[0024] Pioglitazone Hydrochloride 5.5g

[0025] Mannitol 100g

[0026] Poloxamer 15g

[0027] Magnesium Stearate 10g

[0028] Essence 15ml;

[0029] 2) The preparation method of pioglitazone hydrochloride chewable tablet is as follows:

[0030] (a) pioglitazone hydrochloride is passed through a 30-50 mesh sieve, and the auxiliary materials used are passed through a 50-80 mesh sieve for subsequent use; (b) pioglitazone hydrochloride and auxiliary materials are taken by weighing prescription quantities; Put the sham in a mixer and mix until uniform, granulate by rolling and extruding dry method, pass through a 10-40 mesh sieve to obtain dry granules; (d) add stearic acid to the dry granules prepared in (c) Magnesium, talcum powder and food essence are uniformly mixed, sealed for 1 to 3 hours, and pressed into ...

Embodiment 2

[0033] 1) The prescription composition of pioglitazone hydrochloride chewable tablets is as follows, every 1000 pioglitazone hydrochloride chewable tablets contain:

[0034] Pioglitazone Hydrochloride 10.5g

[0035] Mannitol 150g

[0036] Stevia 30g

[0037] Poloxamer 20g

[0038] Magnesium Stearate 10g

[0039] Talc powder 5g

[0040] Essence 20ml;

[0041] 2) The preparation method of pioglitazone hydrochloride chewable tablet is the same as that in Example 1.

Embodiment 3

[0043] 1) The prescription composition of pioglitazone hydrochloride chewable tablets is as follows, every 1000 pioglitazone hydrochloride chewable tablets contain:

[0044] Pioglitazone Hydrochloride 21g

[0045] Aspartame 150g

[0046] Stevia 80g

[0047] Macrogol 2000 10g

[0048] Poloxamer 20g

[0049] Magnesium Stearate 10g

[0050] Talc powder 5g

[0051] Essence 25ml;

[0052] 2) The preparation method of pioglitazone hydrochloride chewable tablet is the same as that in Example 1.

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Abstract

The invention discloses pioglitazone hydrochloride chewable tablets and a preparation method thereof. The pioglitazone hydrochloride chewable tablets have the advantages that: industrial production is easy; a process is simple and convenient; and due to the adoption of dry-method pelletizing, the activity of pioglitazone hydrochloride is maintained farthest and the pioglitazone hydrochloride chewable tablets are convenient to take, chew, suck or swallow by patients without water and are particularly suitable for patients who cannot swallow ordinary tablets. After being seasoned, the pioglitazone hydrochloride chewable tablets are fragrant and sweet and palatable, are convenient to take by the patients, have good compliance, solve the problem that the formulation of the pioglitazone hydrochloride is single, and only capsules and dispersible tablets appear on the market at present, and enrich the choice of doctors and the patients on the formulations.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pioglitazone hydrochloride chewable tablet for metabolic syndromes such as type II diabetes and a preparation method thereof. Background technique [0002] Diabetes mellitus (Diabetes Mellitus) is a syndrome of glucose, protein and lipid metabolism disorders caused by insufficient insulin or defects in insulin cell metabolism. Among diabetic patients, more than 90% are type II diabetes. Type II diabetes, also known as adult-onset diabetes, usually occurs after the age of 35 to 40. The ability to produce insulin in patients with type II diabetes is not completely lost. Some patients even produce too much insulin, but the effect of insulin is greatly reduced. Therefore, the insulin in the patient's body may be in a state of relative deficiency. [0003] Pioglitazone hydrochloride is a thiazolidinedione oral antidiabetic drug, which is a new type of insulin sensitiz...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4439A61P3/10
Inventor蒋明高
Owner蒋明高