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Application of traditional Chinese medicine preparation in treating oral leukoplakia and preventing diseases caused by oral leukoplakia canceration

A technology of traditional Chinese medicine preparation and oral mucosa, which is applied in the field of external preparations of traditional Chinese medicine for the treatment of oral leukoplakia and the prevention of oral leukoplakia cancer. It can solve the problems that it cannot be used as a medicine for oral leukoplakia treatment, it cannot prevent leukoplakia from recurring, and the recurrence rate of retinoic acid treatment is high. , to achieve the effect of avoiding adverse reactions, significant curative effect and low price

Inactive Publication Date: 2011-07-06
TIANJIN KANGCHEN RUIXIN MEDICAL GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The etiology of OLK is complex, the pathogenesis is unknown, and clinically there may be no symptoms, so the focus of treatment should be to prevent or reduce its malignant transformation. Treatment methods include drug therapy and non-drug therapy (surgery, laser, cryotherapy), but the latter has adaptations Symptom limitation and higher recurrence rate, more importantly, it cannot prevent the reoccurrence of leukoplakia in other parts of the oral cavity
At present, commonly used drugs in clinical practice include retinoic acid, bleomycin, propolis, fluorouracil, cyclooxygenase-2 inhibitors, β-carotene, lycopene, etc. These drugs such as bleomycin and fluorouracil There are many side effects of retinoic acid, the recurrence rate of retinoic acid treatment is high, and the price of propolis is relatively expensive, so they cannot be used as the best treatment for oral leukoplakia.

Method used

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  • Application of traditional Chinese medicine preparation in treating oral leukoplakia and preventing diseases caused by oral leukoplakia canceration
  • Application of traditional Chinese medicine preparation in treating oral leukoplakia and preventing diseases caused by oral leukoplakia canceration
  • Application of traditional Chinese medicine preparation in treating oral leukoplakia and preventing diseases caused by oral leukoplakia canceration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1, Zengshengping oral film preparation

[0036] Take 210g of white fresh skin and grind it into fine powder for later use. Then take 100g of xanthophyll seed, 420g each of Shandougen, Patrinia, ginseng and Prunella vulgaris, put them in a container, add an appropriate amount of water, decoct for 2 hours, filter the medicinal liquid, add appropriate amount of water to the dregs, and decoct for 1.5 hours , filter the liquid and discard the residue. The two filtrates were combined and concentrated under reduced pressure to an extract with a relative density of 1.30 to 1.35 (50°C heat test). Add white fresh skin powder, mix and dissolve in 95% ethanol to obtain a mixed solution. Accurately weigh 10 g of sodium carboxymethylcellulose and dissolve it in 500 ml of distilled water, and let it stand for 24 hours to obtain 2% sodium carboxymethylcellulose. Pour the mixed solution into 2% sodium carboxymethylcellulose, add distilled water to 100ml, and stir evenly. A...

Embodiment 2

[0037] Embodiment 2, paste

[0038] Take 230g of white fresh skin and grind it into fine powder for later use. Then take 120g of xanthophyll seed, 480g of mountain bean root, 420g of Patrinia, 420g each of ginseng and Prunella vulgaris, put them in a container, add an appropriate amount of water, cook for 2 hours, filter the medicinal liquid, add appropriate amount of water to the dregs, and cook After 1.5 hours, filter the medicinal solution and discard the residue. The two filtrates were combined and concentrated under reduced pressure to an extract with a relative density of 1.20 to 1.45 (50°C heat test). Finally, evenly mix the spare white fresh skin powder with the concentrated extract, and add an appropriate amount of excipients to make a paste.

Embodiment 3

[0039] Embodiment 3, patch

[0040] prescription:

[0041] Shandougen 420g, boxing ginseng 420g, Beibaijiang 420g, white fresh skin 210g, Prunella vulgaris 420g, xanthate 100g Preparation:

[0042] For the above six flavors, take 105g of white fresh skin and grind it into fine powder, set aside, take the mountain bean root and add water to decoct twice, each time for 1.5 hours, combine the decoction, filter, and the filtrate is concentrated under reduced pressure to a relative density of 1.30-1.35 (50 ℃), dried under reduced pressure (below 60 ℃) into a dry paste, crushed, and set aside. The other four flavors such as boxing ginseng and the remaining white fresh skin 105g, add water and decoct twice, the first time is 2 hours, the second time is 1.5 hours, combine the decoction, filter, and the filtrate is concentrated under reduced pressure to a relative density of 1.30-1.35 (50° C.) thick paste, add white fresh skin powder and mountain bean root dry paste powder, mix and d...

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Abstract

The invention relates to a traditional Chinese medicine externally-applied preparation for treating oral leukoplakia and preventing diseases caused by oral leukoplakia canceration, specifically, a Chinese patent drug prepared from traditional Chinese medicinal herbs. The traditional Chinese medicine externally-applied preparation is prepared from the following traditional Chinese medicine raw materials according to the parts by weight: 18-24 parts of subprostrate soplhor root, 17-21 parts of bistort rhizome, 17-23 parts of dahurian patrinia herb, 8-12 parts of Cortex Dictamni, 18-25 parts of common selfheal spike, and 3-6 parts of airpotato yam.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine preparation, in particular to an external Chinese medicine preparation for treating oral leukoplakia and preventing oral leukoplakia from becoming cancerous. Background technique [0002] Zengshengping Tablets, formerly known as Kangaiyi Pills, is a pure Chinese medicine preparation composed of six herbs: Shandougen, Quanshen, Beibaijiang, Baixianpi, Prunella vulgaris and Huangyaozi. The king medicine is to clear away fire, reduce swelling and relieve sore throat with mountain bean root. Fist ginseng cools blood, activates blood and reduces swelling, Prunella vulgaris clears stagnation, heat, softens and hardens, and the two medicines are ministers. Beibaijiang clears away heat and eliminates stagnation, Baixianpi clears away heat, and Huang Yaozi dissipates stagnation, resolves phlegm and reduces swelling. All the medicines are heat-clearing and detoxifying medicines, cold ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/70A61P1/02A61P35/00
Inventor 朱江辛宏宇蔺莉莉王英实
Owner TIANJIN KANGCHEN RUIXIN MEDICAL GROUP
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