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Application of verbascoside in preparation of medicaments for treating chronic prostatitis

A technology of chronic prostatitis and verbascoside, applied in the field of medicine, can solve problems such as the treatment of chronic prostatitis that has not been seen

Active Publication Date: 2012-07-11
内蒙古天衡医院管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Actascoside is a phenylpropanoid glycoside, which exists in various plants such as Scrophulariaceae, Verbenaceae, Lidanaceae, and Plantaceae. It has antibacterial, anti-inflammatory, antiviral, antitumor, antioxidative, immune regulation, and enhancement Memory, liver protection, heart strengthening and other extensive pharmacological effects, but there is no report on its treatment of chronic prostatitis

Method used

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  • Application of verbascoside in preparation of medicaments for treating chronic prostatitis
  • Application of verbascoside in preparation of medicaments for treating chronic prostatitis
  • Application of verbascoside in preparation of medicaments for treating chronic prostatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Pharmacodynamics test: Effect of verbascoside on rat chronic prostatitis model

[0023] Abstract: Methods: Male SD rats were injected with 25% Xiaozhiling injection into both sides of the dorsal lobe of the prostate to create a chronic prostatitis model. Qianliekang tablets were selected as the positive control drug, and a normal control group, a sham operation group and a model group were set up at the same time. After modeling, the drugs were administered by intragastric administration for 30 days. The curative effect of the drug was evaluated by measuring the wet weight of the prostate, calculating the prostate index, measuring the volume of the prostate by the drainage method, and conducting histological examination. Results: The test substance verbascoside 30mg / kg, 60mg / kg significantly inhibited the rat chronic prostatitis model induced by Xiaozhiling injection, and could significantly reduce the wet weight, volume and prostate index of the prostate, wh...

Embodiment 2

[0060] Embodiment 2, tablet

[0061] The verbascoside is evenly mixed with suitable auxiliary materials, and compressed into tablets.

[0062] prescription:

[0063] Name Prescription Amount

[0064] Verbacoside 100g

[0065] Microcrystalline Cellulose 100g

[0066] Starch 40g

[0067] Sodium carboxymethyl starch 10g

[0068] Anhydrous ethanol amount

[0069] Magnesium Stearate 3g

[0070] Make 1000 tablets

[0071] Preparation Process:

[0072] (1) Verbacoside is pulverized and passed through a 100-mesh sieve, microcrystalline cellulose and starch are passed through a 60-mesh sieve, and set aside;

[0073] (2) Verbacoside, microcrystalline cellulose, starch, sodium carboxymethyl starch take by weighing prescription quantity and mix uniformly;

[0074] (3) Adhesive: absolute ethanol;

[0075] (4) Add appropriate amount of binder to make soft material, granulate with 24 mesh, dry at 40°C, add prescription amount of magnesium stearate, granulate with 2...

Embodiment 3

[0077] Embodiment 3, capsule

[0078] Mix verbascoside with suitable auxiliary materials evenly, directly fill or make granules and fill in empty capsules to obtain the product.

[0079] prescription:

[0080] Name Prescription Amount

[0081] Verbacoside 100g

[0082] Microcrystalline Cellulose 80g

[0083] Starch 40g

[0084] Sodium carboxymethyl starch 10g

[0085] Anhydrous ethanol amount

[0086] Magnesium Stearate 2g

[0087] Make 1000 capsules

[0088] Preparation Process:

[0089] (1) Verbacoside is pulverized and passed through a 100-mesh sieve, microcrystalline cellulose and starch are passed through a 60-mesh sieve, and set aside;

[0090] (2) Verbacoside, microcrystalline cellulose, starch, sodium carboxymethyl starch take by weighing prescription quantity and mix uniformly;

[0091] (3) Adhesive: absolute ethanol;

[0092] (4) Add appropriate amount of binder to make soft material, granulate with 24 mesh, dry at 40°C, add prescriptio...

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Abstract

The invention discloses new application of verbascoside, in particular application of the verbascoside in the preparation of medicaments for treating chronic prostatitis and application of the verbascoside serving as an active ingredient in the preparation of compound preparations. Researches show that the verbascoside has an obvious suppressing effect on chronic prostatitis model rats, and the treating effect is better than that of Prostate Plus.

Description

technical field [0001] The invention relates to the use of verbascoside in the preparation of medicines for treating chronic prostatitis, belonging to the field of medicine. Background technique [0002] Chronic prostatitis is a common disease in adult males. The incidence rate of adults over 25 years old is 35% to 40%. The etiology is complex and easy to relapse, which seriously affects the quality of life of males. Due to the special physiological structure of the prostate, it is difficult for drugs to enter the gland to achieve an effective concentration. Currently, commonly used therapeutic drugs such as antibiotics, anti-inflammatory drugs, α receptor blockers, herbal medicines, and immunosuppressants have poor therapeutic effects, Low cure rate, many adverse reactions and other defects. [0003] Verbacoside, the English name is Verbascoside, and its structural formula is shown in Formula 1. [0004] [0005] Formula 1 [0006] CAS Registry Number (CAS RegistryNum...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61P13/08
Inventor 刘成林
Owner 内蒙古天衡医院管理有限公司