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Preparation method of regenerated silk fibroin fiber and product thereof

A technology for regenerating silk fibroin and fibers, applied in the field of microfluidic spinning, can solve problems such as the inability to meet animal silk proteins, and achieve the effects of avoiding pollution and damage, reducing production costs, and controlling degradation.

Active Publication Date: 2012-08-29
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although these patents use water as the solvent for silk fibroin, the process is green and environmentally friendly, but the spinning process is only a simple wet spinning or dry spinning, and the structure of the spinning head is simple, which cannot imitate the spinning technology of spiders or silkworms. The shearing, stretching or dynamic regulation of the composition of animal silk protein in the spinner cannot meet the various conditions required for the assembly of animal silk protein

Method used

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  • Preparation method of regenerated silk fibroin fiber and product thereof
  • Preparation method of regenerated silk fibroin fiber and product thereof
  • Preparation method of regenerated silk fibroin fiber and product thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A kind of preparation method of regenerated silk fibroin fiber of the present invention, use the regenerated silk fibroin protein aqueous solution of 30% mass percentage concentration as spinning liquid, under the temperature condition of 30 ℃, inject the spinning liquid at the flow rate of 0.5 μ L / min In the microfluidic chip, after being extruded from the outlet of the microfluidic channel of the microfluidic chip, it is solidified into filaments in the air and wound on the upper roller; the air gap from the spinneret to the winding roller is 1cm, and the winding speed is 1cm / s .

[0036] The microfluidic chip includes a substrate and a membrane, the membrane has grooves, and the grooved surface of the membrane is bonded to the substrate to form a microfluidic channel; as figure 1 and 2 As shown, the depth c of the whole microfluidic channel is equal to 10 μm, and the width b of the microfluidic channel gradually and continuously decreases from the inlet 1 to the outle...

Embodiment 2

[0040] A method for preparing regenerated silk fibroin fibers of the present invention uses an aqueous solution of regenerated silk fibroin with a mass percent concentration of 60% as the spinning liquid, and injects the spinning liquid into the microfiber at a flow rate of 10 μL / min at a temperature of 20°C. In the fluidic chip, after being extruded from the outlet of the microfluidic channel of the microfluidic chip, it is solidified into filaments in the air and wound on the upper roller; the air gap from the spinneret to the winding roller is 5 cm, and the winding speed is 5 cm / s.

[0041] The microfluidic chip includes a substrate and a membrane, the membrane has grooves, and the grooved surface of the membrane is bonded to the substrate to form a microfluidic channel; as figure 1 and 2 As shown, the entire depth c of the microfluidic channel is equal to 500 μm, and the width b of the microfluidic channel gradually and continuously decreases from the inlet 1 to the outlet...

Embodiment 3

[0045] A kind of preparation method of the regenerated silk fibroin fiber of the present invention, use the regenerated silk fibroin aqueous solution of 45% mass percentage concentration as the spinning solution, inject the spinning solution into the microfiber at a flow rate of 5 μL / min under the temperature condition of 10°C In the fluidic chip, after being extruded from the outlet of the microfluidic channel of the microfluidic chip, it is solidified into filaments in the air and wound on the upper roller; the air gap from the spinneret to the winding roller is 10 cm, and the winding speed is 3 cm / s.

[0046] The microfluidic chip includes a substrate and a diaphragm, the diaphragm has a groove, and the surface of the diaphragm with the groove is bonded to the substrate to form a microfluidic channel; the depth c of the whole process of the microfluidic channel is equal to 100 μm, the width b of the microfluidic channel gradually and continuously decreases from the inlet 1 t...

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Abstract

The invention belongs to the technical field of microfluid spinning and relates to a preparation method of regenerated silk fibroin fiber and a product thereof. The preparation method of the regenerated silk fibroin fiber comprises the following steps of adopting a regenerated silk fibroin aqueous solution as a spinning solution, injecting the spinning solution into a microfluid chip in a temperature range of 10-30 DEG C, extruding the spinning solution at an outlet of a microfluid passage of the microfluid chip, and then solidifying the extrudate into silk in the air and rolling the silk on a spool. The microfluid chip comprises a substrate and a membrane; the membrane is provided with a groove; the surface of the membrane with the groove is bound with the substrate to form the microfluid passage; the whole-course depth c of the microfluid passage is equal; and the width b of the microfluid passage is gradually and continuously reduced from an inlet to the outlet. In the method, the microfluid passage is designed by taking the spinning process of a spider or a silkworm as a start point, and the regenerated animal silk fibroin fiber with excellent performances is obtained through cutting and extension by adopting a microfluid dry spinning process with a higher bionic degree and taking the regenerated silk fibroin aqueous solution with high concentration as the spinning solution.

Description

technical field [0001] The invention belongs to the technical field of microfluid spinning, and relates to a preparation method of regenerated silk fibroin fiber and its products, in particular to a microfluid dry spinning method using a high-concentration regenerated silk fibroin protein aqueous solution as the spinning stock solution. Methods and articles thereof. Background technique [0002] In recent years, the application of microfluidic chips in fiber formation is attracting increasing attention. Microfluidic technology can be spun under normal temperature and pressure conditions, which is very suitable for the processing of materials such as biomacromolecules. At present, microfluidic spinning technology has been well applied in the fields of instant spinning and electrospinning. In addition, the microfluidic spinning system may regulate the composition and structure of the spinning solution through the laminar flow and diffusion characteristics of the microfluid, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01D5/04D01D4/02D01F4/02
Inventor 张耀鹏罗杰邵惠丽胡学超
Owner DONGHUA UNIV
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