Kit for detecting acute myeloid leukemia susceptibility

An acute myeloid and kit technology, applied in the field of kits for detecting the susceptibility of acute myeloid leukemia, can solve the problem of not predicting acute myeloid leukemia, and achieve the effect of wide application
CN102146441AInactive Publication Date: 2011-08-10SUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SUZHOU UNIV
Publication Date
2011-08-10
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention relates to a kit for detecting disease susceptibility. The susceptibility of acute myeloid leukemia is predicted by detecting a single nucleotide polymorphism (SNP) site of mitogen activated protein kinase 4 (CD44). The kit comprises a fluorescence quantitative polymerase chain reaction (PCR) conventional component, a specific primer pair for detecting the No.rs11821102 SNP site of the CD44 and a specific fluorescence probe pair. The kit can detect the gene type of the No.rs11821102 SNP site on the CD44 gene of DNA so as to detect the susceptibility of individual acute myeloid leukemia, is also suitable for prognostic detection of gastric cancer, prostatic cancer and ovarian cancer, and can be widely applied in medicinal research.
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Description

technical field

[0001] The invention relates to a kit for detecting disease susceptibility, in particular to a kit for detecting susceptibility to acute myeloid leukemia, by detecting the single nucleotide polymorphism of mitogen-activated protein kinase kinase 4 (CD44) (SNP) loci to predict susceptibility to acute myeloid leukemia. Background technique

[0002] The number of cases of hematological malignancies worldwide is about 400,000, accounting for the sixth place among all kinds of malignancies. The annual new cases in China are about 250,000, accounting for the eighth place among malignant tumors in my country. The occurrence of cancer is a multi-factor, multi-stage, multi-gene mutation process. As a key molecule of cell surface function, CD44 is involved in various important processes of tumorigenesis and development. A large number of studies have shown that the single nucleotide polymorphisms of genes related to tumor immune regulation can affect the role of the...

Claims

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