Novel hemorheology quality control combination containing polyalcohol
A composition and polyol technology, applied in the field of blood rheological index detection, can solve the problems of long-term stability and rheological reproducibility to be confirmed, and achieve the effect of changing rheological properties and improving correspondence
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Embodiment 1
[0031] (1), preparation of hemorheological quality control composition 1 containing 0.1% polyoxypropylene glycol
[0032] Add 0.1g of polyoxypropylene glycol to 99.9g of plasma, wherein the plasma is anticoagulated with heparin sodium with a concentration of 0.1mg / ml, and 0.1ml of sodium azide is used as a preservative, and after mixing, it is subpackaged by aseptic technique. Tube 5ml, store at -20°C.
[0033] (2), whole blood / plasma viscosity and composition 1 fitting experiment
[0034] Take normal blood samples, adjust the hematocrit to 42%, measure for 10, 60, 150s -1 The whole blood apparent viscosity and plasma viscosity within the range of the shear rate are compared with the viscosity curve of composition 1. The change curve of plasma and composition 1 viscosity with shear rate is as follows figure 1 Shown, where the unit of shear rate is s -1 , the viscosity unit is: mPa.s, figure 1 The curve marked with "□" is the plasma viscosity change curve, and the one mark...
Embodiment 2
[0044] (1), preparation of blood rheological quality control composition containing 0.2% polyethylene adipate diethylene glycol ester 2
[0045] Add 0.2 g of polyethylene adipate diethylene glycol ester glycol to 99.8 g of serum, wherein the serum is anticoagulated with heparin sodium with a concentration of 0.1 mg / ml, and 0.1 ml of sodium azide is used as a preservative. Dispense by aseptic technique, 5ml per tube, and store at -20°C.
[0046] (2), whole blood / serum viscosity and composition 2 fitting experiment
[0047] Take normal blood samples, adjust the hematocrit to 42%, measure for 10, 60, 150s -1 The whole blood apparent viscosity and serum viscosity within the range of the shear rate are compared with the viscosity curve of composition 2 for fitting degree. The comparison results show that the serum viscosity does not change with the shear rate, but the apparent viscosity of composition 2 containing 0.2% polyethylene adipate diol decreases with the increase of the ...
Embodiment 3
[0057] (1), preparation of blood rheological quality control composition containing 40% glycerin 3
[0058] Add 40g of glycerin to 60g of blood plasma, among which the blood plasma is anticoagulated with heparin sodium with a concentration of 0.1mg / ml, and 0.1ml of sodium azide is used as a preservative. 20°C environment.
[0059] (2), whole blood / plasma viscosity and composition 3 fitting experiment
[0060] Take normal blood samples, adjust the hematocrit to 42%, measure for 10, 60, 150s -1 The whole blood apparent viscosity and plasma viscosity within the range of the shear rate are compared with the viscosity curve of composition 3 for fitting degree. The comparison results showed that the viscosity of plasma did not change with the shear rate, but the apparent viscosity of composition 3 containing 40% glycerol decreased with the increase of the shear rate, showing a non-Newtonian fluid.
[0061] in 10s -1 The apparent viscosity is the initial viscosity, and the appare...
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