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Novel hemorheology quality control combination containing polyalcohol

A composition and polyol technology, applied in the field of blood rheological index detection, can solve the problems of long-term stability and rheological reproducibility to be confirmed, and achieve the effect of changing rheological properties and improving correspondence

Inactive Publication Date: 2011-08-10
SHENZHEN SYDSCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the long-term stability and rheological reproducibility of the above technical solutions have yet to be confirmed

Method used

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  • Novel hemorheology quality control combination containing polyalcohol
  • Novel hemorheology quality control combination containing polyalcohol
  • Novel hemorheology quality control combination containing polyalcohol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1), preparation of hemorheological quality control composition 1 containing 0.1% polyoxypropylene glycol

[0032] Add 0.1g of polyoxypropylene glycol to 99.9g of plasma, wherein the plasma is anticoagulated with heparin sodium with a concentration of 0.1mg / ml, and 0.1ml of sodium azide is used as a preservative, and after mixing, it is subpackaged by aseptic technique. Tube 5ml, store at -20°C.

[0033] (2), whole blood / plasma viscosity and composition 1 fitting experiment

[0034] Take normal blood samples, adjust the hematocrit to 42%, measure for 10, 60, 150s -1 The whole blood apparent viscosity and plasma viscosity within the range of the shear rate are compared with the viscosity curve of composition 1. The change curve of plasma and composition 1 viscosity with shear rate is as follows figure 1 Shown, where the unit of shear rate is s -1 , the viscosity unit is: mPa.s, figure 1 The curve marked with "□" is the plasma viscosity change curve, and the one mark...

Embodiment 2

[0044] (1), preparation of blood rheological quality control composition containing 0.2% polyethylene adipate diethylene glycol ester 2

[0045] Add 0.2 g of polyethylene adipate diethylene glycol ester glycol to 99.8 g of serum, wherein the serum is anticoagulated with heparin sodium with a concentration of 0.1 mg / ml, and 0.1 ml of sodium azide is used as a preservative. Dispense by aseptic technique, 5ml per tube, and store at -20°C.

[0046] (2), whole blood / serum viscosity and composition 2 fitting experiment

[0047] Take normal blood samples, adjust the hematocrit to 42%, measure for 10, 60, 150s -1 The whole blood apparent viscosity and serum viscosity within the range of the shear rate are compared with the viscosity curve of composition 2 for fitting degree. The comparison results show that the serum viscosity does not change with the shear rate, but the apparent viscosity of composition 2 containing 0.2% polyethylene adipate diol decreases with the increase of the ...

Embodiment 3

[0057] (1), preparation of blood rheological quality control composition containing 40% glycerin 3

[0058] Add 40g of glycerin to 60g of blood plasma, among which the blood plasma is anticoagulated with heparin sodium with a concentration of 0.1mg / ml, and 0.1ml of sodium azide is used as a preservative. 20°C environment.

[0059] (2), whole blood / plasma viscosity and composition 3 fitting experiment

[0060] Take normal blood samples, adjust the hematocrit to 42%, measure for 10, 60, 150s -1 The whole blood apparent viscosity and plasma viscosity within the range of the shear rate are compared with the viscosity curve of composition 3 for fitting degree. The comparison results showed that the viscosity of plasma did not change with the shear rate, but the apparent viscosity of composition 3 containing 40% glycerol decreased with the increase of the shear rate, showing a non-Newtonian fluid.

[0061] in 10s -1 The apparent viscosity is the initial viscosity, and the appare...

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Abstract

The invention relates to a hemorheology quality control combination containing polyalcohol. The novel hemorheology quality control combination comprises the following components in percentage by weight: 60 to 99.99 percent of first component and 0.01 to 40 percent of second component, wherein the first component comprises blood plasma or blood serum, and the second component comprises the polyalcohol; and non-Newtonian fluid of which the apparent viscosity and the shear rate are in an inverse proportion is formed by the first component and the second component. In the novel hemorheology quality control combination containing the polyalcohol, the interaction among molecules inside the blood plasma or the blood serum is changed by adding the polyalcohol into the blood plasma or the blood serum to make the polyalcohol inserted among protein molecule chains of the blood plasma or the blood serum, so that the rheological properties of blood plasma solution or blood serum solution are changed to ensure that the viscosities of whole blood or the blood plasma both endow with better correspondence. Moreover, the novel hemorheology quality control combination containing the polyalcohol can be used as a standard sample or a quality control sample in a hemorheology clinical test during detection on blood viscosity.

Description

technical field [0001] The invention relates to blood rheology index detection technology in the field of medical diagnosis, and more specifically relates to a novel blood rheology quality control composition containing polyalcohol. Background technique [0002] The most basic indicators of macroscopic clinical hemorheology testing should include the determination of whole blood viscosity, plasma viscosity, hematocrit and plasma fibrinogen. Blood is a complex non-Newtonian fluid whose apparent viscosity varies with shear rate and shear time. The quality control of hemorheology testing is quite complicated, and due to the lack of standard reference materials, the clinical data of hemorheology detected by different hospitals and instruments are not comparable, which affects the clinical application of hemorheology testing. Therefore, developing a suitable hemorheological quality control substance is a problem concerned by those skilled in the art. [0003] Some related studi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/96G01N11/00
Inventor 王艳平修宏宇张文阁刘牧龙
Owner SHENZHEN SYDSCI TECH
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