Device and method for optically parallel analysis of sample arrangement and corresponding manufacturing method
An optical device and sample technology, applied in the direction of material analysis, chemical instruments and methods, and measuring devices through optical means, can solve the problem of signal-to-noise ratio reduction, achieve high signal-to-noise ratio, improve sensitivity, and suppress optical pollution Effect
Inactive Publication Date: 2015-10-28
ROBERT BOSCH GMBH
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Problems solved by technology
In this regard, the light beam ST is a disturbing beam and reduces the signal-to-noise ratio of the sample area K1
Method used
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[0027] In the figures, identical reference numbers indicate identical or functionally identical elements.
[0028] figure 1 is a schematic diagram of a device for optically parallel analysis of sample arrangements in the form of a microtiter plate according to a first embodiment of the invention.
[0029] exist figure 1 , reference numeral 1 designates a plastic carrier substrate in the form of a microtiter plate. as reference Figure 4 Like the microtiter plate described, the carrier substrate 1 has cavities K1 , K2 as sample regions for receiving sample substances A1 , A2 . The sample areas K1 , K2 , etc. are usually arranged in a matrix on the rectangular carrier substrate 1 . The carrier substrate 1 has a thickness H between 2-4mm P . The thickness of the sample area K1, K2 is H W Indicates and is usually 0.6-0.8mm.
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A device and a method for optical parallel analysis of a sample arrangement. The device includes a system of sample areas provided on and / or in a front face of the carrier substrate for receiving a sample substance; a system of detector areas provided on and / or in a back face of the carrier substrate, each detector area being assigned to a corresponding sample area; and a system of optical devices, each optical system being assigned to a corresponding sample area and being designed in such a way that it deflects light beams, which the corresponding sample area in response to an optical excitation does not emit in the direction of a detector area assigned to it, in the direction of the detector area assigned to it and / or in the direction of a detector-free area on the back face of the carrier substrate.
Description
technical field [0001] The invention relates to a device and a method for optically parallel analysis of a sample arrangement and a corresponding production method. Background technique [0002] Although any desired device can be used for the optically parallel analysis of the sample arrangement, the invention and the problem on which it is based will be explained with regard to the use on microtiterplates. [0003] For the optical investigation of biochemical individual samples, microtiter plates or DNA chips are generally used, in which the study objects are arranged spatially separated from one another in discrete sample areas. By performing optical analyzes on a large number of individual samples in parallel, results are obtained faster than if the individual analyzes were performed sequentially. Reagents are also saved by miniaturizing the individual recipes. [0004] Microtiter plates are usually rectangular and contain a number of small plates in isolated rows and c...
Claims
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IPC IPC(8): G01N21/63G01N21/03G01N33/483
CPCG01N21/645B01L3/5085B01L2200/026B01L2200/141B01L2300/0654G01N21/0303G01N2021/6463G01N2021/6482G01N2201/064Y10T29/49908Y10T29/4998
Inventor M.多布J.鲁普
Owner ROBERT BOSCH GMBH