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Tendon-relaxing and blood-activating capsules and preparation process thereof

A technology for relaxing tendons and promoting blood circulation and capsules is applied in the directions of capsule delivery, medical preparations containing active ingredients, plant raw materials, etc., which can solve the problems of large dosage, slow disintegration, low bioavailability and the like, and achieves a simple preparation process, The effect of complete extraction and reduced dosage

Active Publication Date: 2012-12-05
杭州华东医药集团康润制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention overcomes the technical defects of slow disintegration, large dosage and low bioavailability in the prior art, and provides a high-efficiency Shujinhuoxue capsule

Method used

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  • Tendon-relaxing and blood-activating capsules and preparation process thereof
  • Tendon-relaxing and blood-activating capsules and preparation process thereof
  • Tendon-relaxing and blood-activating capsules and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: extraction condition research and test

[0025] 1. Selection of pH value and extraction times

[0026] (1) Factor level inspection

[0027] Add 10 times the amount of water to decoct 2.2g of natural copper for 2 hours. 3.5g of safflower, 13.2g of Cyperus cyperi, 17.5g of dog ridge, 8.7g of cypress bark, 13.2g of terrazzo vine, 13.2g of safflower, 13.2g of eupatorium leaves, 17.5g of mistletoe, 13.2g of milletanus, The pH value of acid extraction, the pH value of alkali extraction, the number of times of acid extraction, and the number of times of alkali extraction were used as the investigation factors, and three different levels were selected for each factor. The factor levels are shown in Table 1. Taking the content of hydroxysafflower yellow A (mg / grain) as the investigation index, determine the best process, and do the orthogonal test according to the L9(34) table.

[0028] Table 1 Factor level table

[0029]

[0030] (2) Orthogonal test plan an...

Embodiment 2

[0054] Embodiment 2: Preparation of Shujin Huoxue Capsules

[0055] Prescription: safflower 35g, Rhizoma Cyperi (made) 132g, dog ridge (made) 175g, xiangjiapi 87g, genus 132g, Shenjincao 132g, Eupatorium leaves 132g, mistletoe 175g, Millipeda 132g, natural Copper (calcined) 22g, appropriate amount of dextrin.

[0056] Preparation method: Add 10 times the amount of natural copper to water and decoct for 2 hours, filter and set aside. Safflower, Rhizoma Cyperi, Dog Ridge, Cyperus barbatus, Pterocarpus vine, Grass chinensis, Eupatorium leaves, mistletoe, Millae Spatholobus are crushed into fine powder, passed through a No. 5 sieve, and the pH value is 8 times the amount added for the first time 2. The concentration is 60% ethanol, which is extracted for 2 hours in a slightly boiling state, and a juice is released. For the second time, 8 times the amount of ethanol with a pH value of 9 and a concentration of 60% was extracted for 1 hour in a slightly boiling state, and the secon...

Embodiment 3

[0057] Example 3: Shujin Huoxue Capsules

[0058] Prepare according to the example described in the patent "Shujin Huoxue Capsule and Its Preparation Method" (Patent No. 200610031734.1). The raw materials are: 21g of safflower, 78.6g of Cyperus cyperi (manufactured), 104.8g of dog ridge (manufactured), 52.4g of xiangjia bark, 78.6g of terrazzo vine, 78.6g of genus chinensis, 78.6g of eupatorium leaves, mistletoe 104.8g, Caulis Spatholobus 78.6g, natural copper (calcined) 13.1g; auxiliary material starch 28-30g.

[0059] The preparation process is as follows: crush safflower, Cyperi cyperi, dog ridge, and cypress bark into fine powder, sieve; add 8 times the amount of natural copper to boil for 2 hours, and then add safflower, cyperus, and eupatorium leaves , mistletoe, and Caulis Spatholobus decoction twice, add 12 times the amount of water for 3 hours for the first time, add 10 times the amount of water for 2 hours for the second time, combine the decoction, filter, let stan...

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Abstract

The invention discloses tendon-relaxing and blood-activating capsules and a preparation process thereof. In the invention, through the improvement on the preparation process, the active ingredient content in the tendon-relaxing and blood-activating capsules is improved and the bioavailability is improved, so the dosage is reduced. The extraction method disclosed by the invention is simple and convenient and is favorable for industrial production.

Description

technical field [0001] The invention belongs to traditional Chinese medicine preparations, and mainly relates to a Shujin Huoxue capsule and a preparation process thereof. Background technique [0002] Shujinhuoxue Tablets are included in the Thirteenth Volume of Traditional Chinese Medicine Prescriptions in the "Drug Standards of the Ministry of Health of the People's Republic of China" (hereinafter referred to as the standard), and belong to the national essential medicines and medical insurance catalogues. Due to the large number of manufacturers of Shujinhuoxue Tablets, the quality of the products is uneven; in terms of technology, direct crushing and partial water extraction are used to prepare the preparations. The tablet preparation process needs to add several kinds of excipients for compression molding, which has a long disintegration time and slow dissolution. Large amount (3 times a day, 5 tablets at a time) and low bioavailability. [0003] The preparation proce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8905A61K9/48A61P19/00A61P29/00A61K33/26
Inventor 王维周建仁彭腊梅
Owner 杭州华东医药集团康润制药有限公司
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