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Comprehensive use of ovateleaf holly bark medicinal material

A technology for extracting syringin and medicinal materials, which is applied in the field of simultaneously extracting syringin, syringin, total saponins of syringin, and pelicin, which can solve the problem of undisclosed components and contents of total saponins, and difficulty in quality control, etc. Problems, easy to control product quality, easy to operate, improve the effect of myocardial ischemia

Active Publication Date: 2012-11-14
安士制药(中山)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Bingying is a medicinal material with a wide range of uses. Chinese patent CN101032534A discloses the preparation method of total glycosides of Bingying and its application in diseases of the cardiovascular and cerebrovascular systems. The total saponins obtained are actually an extract of Jubing, because there is no chemical data in the patent to indicate that it is a saponin, and the composition and content of the total saponins are not indicated, so the quality is difficult to control

Method used

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  • Comprehensive use of ovateleaf holly bark medicinal material
  • Comprehensive use of ovateleaf holly bark medicinal material
  • Comprehensive use of ovateleaf holly bark medicinal material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Rescue 1Kg of Bing herbs, crush them into coarse powder, add water to decoct twice, each time for 2 hours, add 10kg of water for the first time, add 7Kg of water for the second time, combine the decoction, filter, 2 medicinal residues for use, and 1 concentrated filtrate To 0.3Kg, add 0.6Kg ethanol, let it stand for 24 hours, filter, the filtrate, namely alcohol precipitation solution 3, is concentrated to 200g dilute extract 4, add 150g silica gel to disperse and mix well, dry to obtain silica gel dry paste powder 5, and place it in continuous circulation for extraction In the separator, use dichloromethane: ethanol volume ratio is 1300ml reflux extraction of the mixed solvent of 1: 0.1, until the effluent in the separator checks that there is no syringin with thin layer chromatography, obtains the organic solvent extract 6, Recover the solvent to dryness to obtain syringin extract 7, then heat and reflux with 320ml of methanol:dichloromethane mixed solvent with a volum...

Embodiment 2

[0070] Rescue 1Kg of Bing medicinal materials, crush them into coarse powder, add water to decoct twice, each time for 2 hours, add 8kg of water for the first time, add 6Kg of water for the second time, combine the decoction, filter, 2 medicinal residues for standby, and 1 concentrated filtrate To 0.4Kg, add 1.6Kg ethanol, let it stand for 24 hours, filter, concentrate the filtrate 3 to 200g of dilute extract 4, add 150g of silica gel to disperse and stir evenly, and place the dried silica gel powder 5 in a continuous circulation extraction separator In, use dichloromethane: methanol volume ratio is 1200ml reflux extraction of the mixed solvent of 1: 0.02, until the effluent in the separator checks that there is no syringin by thin layer chromatography, the organic solvent extraction solution 6 reclaims the solvent to dryness The syringin extract 7 was obtained, and then 250 ml of a mixed solvent with a volume ratio of methanol:chloroform of 1:0.2 was heated and refluxed for di...

Embodiment 3

[0074] Rescue 1Kg of Bing herbs, crush them into coarse powder, add water to decoct twice, each time for 2 hours, add 8kg of water for the first time, add 8Kg of water for the second time, combine the decoction, filter, 2 medicinal residues for use, and 1 concentrated filtrate To 0.5Kg, add 1.5Kg ethanol, let it stand for 24 hours, filter, concentrate the filtrate 3 to 200g of dilute extract 4, add 150g of silica gel to disperse and stir evenly, and place the dried silica gel powder 5 in a continuous circulation extraction separator 1,200ml of acetone was used to reflux and extract until the effluent in the separator was checked by thin layer chromatography for no syringin. The organic solvent extract 6 recovered the solvent until it was dry to obtain syringin extract 7, and then used ethanol: chloroform 300ml of a mixed solvent with a volume ratio of 1:3 was heated under reflux to dissolve, filtered, and the filtrate 8 was left to stand, and the precipitate was collected by fi...

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Abstract

The invention discloses the comprehensive use of an ovateleaf holly bark medicinal material, which relates to method for extracting and separating from plants and use in field of medicines, in particular to a method for extracting syringin, pedunculoside, ovateleaf holly bark acid and ovateleaf holly bark total saponins from an ovateleaf holly bark medicinal material and use. In the invention, the syringing is prepared from water extract solution of the ovateleaf holly bark medicinal material, the pedunculoside and ovateleaf holly bark acid are prepared from medicine slag obtained after waterextraction from the ovateleaf holly bark medicinal material, the purities of the syringin, pedunculoside and ovateleaf holly bark acid are all over 98 percent, and the ovateleaf holly bark total saponins are extracted from the medicine slag obtained after the water extraction from the ovateleaf holly bark medicinal material. The ovateleaf holly bark total saponins can be used for preparing medicines for preventing and treating hyperlipemia, medicines for relieving myocardial ischemia and angina and medicines for treating inflammation and pain. The invention has the advantages that: four active ingredients can be obtained from the ovateleaf holly bark medicinal material and resources can be fully utilized; and 2, the raw materials are readily available, the process is simple, the quality is controllable and batch production can be performed.

Description

technical field [0001] The invention relates to an extraction and separation method derived from plants in the field of medicine and its application, in particular to a method and application for simultaneously extracting syringin, pelicin, japonica acid and cubiying total saponins from cubiying medicinal materials. Background technique [0002] The Chinese herbal medicine Jiubing is the dried bark of Ilex rotunda Thunb., a plant of the Ilex family. It is widely distributed in various provinces in southern China, mainly produced in Guangxi and Guangdong provinces. It is commonly used in the folk for clearing away heat and detoxification, reducing swelling and pain, and treating colds and fevers. , Acute and chronic hepatitis, acute gastroenteritis, gastric and duodenal ulcers, rheumatic joint pain. There are not many research reports on the chemical constituents of Gyubing. In the literature "Research on the Chemical Constituents of Gyubing", Chinese Herbal Medicine, 1991, 2...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P3/06A61P9/10A61P29/00
Inventor 徐清波刘国樵徐孝先王武平李家炜
Owner 安士制药(中山)有限公司
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