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Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors

A compound and substituent technology, applied in the preparation of organic compounds, anti-inflammatory agents, drug combinations, etc., can solve the problems of insufficient efficacy of severe pain, mucosal ulcers, etc.

Active Publication Date: 2011-10-19
ARRAY BIOPHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nonsteroidal anti-inflammatory analgesics (NSAIDs, such as COX-1 or COX-2) also have drawbacks including insufficient potency for severe pain
In addition, COX-1 inhibitors can cause mucosal ulceration

Method used

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Examples

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Effect test

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example 1

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PUM

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Abstract

Compounds of formula (I): in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor. The formula (I) is shown in the description.

Description

technical field The present invention relates to novel compounds, pharmaceutical compositions comprising these compounds, processes for the preparation of these compounds and the use of these compounds in therapy. More specifically, the present invention relates to certain substituted imidazo[1,2-b]pyridazine compounds that exhibit Trk family protein tyrosine kinase inhibition and are useful in the treatment of pain, inflammation, cancer and certain infections disease. Background technique Current treatment regimens for painful conditions utilize several classes of compounds. Opioids such as morphine have several drawbacks including causing vomiting, constipation and negative respiratory effects, as well as possible addiction. Non-steroidal anti-inflammatory analgesics (NSAIDs, eg of type COX-1 or COX-2) also have drawbacks including insufficient potency in treating severe pain. In addition, COX-1 inhibitors can cause mucosal ulceration. Accordingly, there is a continuin...

Claims

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Application Information

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IPC IPC(8): C07D471/04A61K31/5025A61P29/00
CPCC07D487/04A61K31/5025A61K31/5377A61K31/541A61P1/02A61P11/06A61P15/12A61P17/04A61P17/06A61P19/00A61P19/02A61P19/08A61P19/10A61P25/00A61P25/04A61P25/28A61P29/00A61P33/00A61P33/02A61P33/10A61P35/00A61P35/04A61P43/00C07D471/04C07D519/00Y02A50/30C07C51/412C07C53/18
Inventor 史蒂文.W.安德鲁斯朱莉娅.哈斯蒋于桐张敢
Owner ARRAY BIOPHARMA
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