A kind of preparation method of traditional Chinese medicine oral liquid preparation for treating infantile cold

Abstract

A preparation method of a traditional Chinese medicinal oral liquid preparation for treating children's cold belongs to the technical field of traditional Chinese medicine preparation, and comprises the following steps of: distilling mint and Spica Schizonepetae to obtain a volatile oil; distilling apricot kernel to obtain an almond juice; decocting great burdock achene, Baikal skullcap root, balloonflower root, radix peucedani, Angelica dahurica, cape jasmine, haw, medicated leaven, malt, Rhizoma Phragmitis, honeysuckle flower and weeping forsythia by adding water to obtain a water decoction, followed by filtering and condensation to obtain a water extract concentrated solution, and carrying out pretreatment to obtain a pretreatment solution; purifying the pretreatment solution by a membrane to obtain a traditional Chinese medicinal supernatant; carrying out clathration on the volatile oil by the use of a beta-cyclodextrin derivative to obtain a volatile oil clathrate aqueous solution; adding the volatile oil clathrate aqueous solution and pharmaceutic adjuvants into the traditional Chinese medicinal supernatant, boiling to dissolve, adding the almond juice, and naturally coolingto obtain the traditional Chinese medicinal compound oral liquid preparation. With the volatile oil packed by the beta-cyclodextrin derivative, the taste of the traditional Chinese medicinal oral liquid is improved, the quality of the product is stabilized, and the clarity of the product stored for a long time is observably raised.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparation, and in particular relates to a preparation method of a traditional Chinese medicine oral liquid preparation. Background technique [0002] Influenza is an acute upper respiratory disease caused by a cold virus. It is the most common clinical disease in children. Children are prone to expectoration and stagnation after illness. The symptoms are: high fever, loss of appetite, restless sleep, frequent coughing, etc. At present, the traditional Chinese medicine commonly used to treat children's colds is Xiaoermaoningning. In its formula, peppermint and burdock fruit are pungent and cool to relieve the exterior, evacuate wind-heat, relieve sore throat and reduce swelling; Clearing away heat and dampness; honeysuckle and forsythia clearing away heat and detoxifying; reed root clearing away heat and promoting body fluid; almonds, platycodon grandiflorum and peucedanum ex...

AI Technical Summary

Problems solved by technology

These volatile oils are insoluble in water, volatile, and have a bad taste. The patent application number CN200410081639.3 uses β-cyclodextrin inclusion volatile oils to cover the taste and stabilize the volatile oil components in Xiaoerganmaoning. However, due to the β-cyclodextrin Dextrin derivatives are poor in water solubility, and the β-cyclodextrin inclusion complex formed by inclusion of volatile oil is even poorer in water solubility, which affects the stability of liquid preparations

In addition, due to the complex components of traditional Chinese medicine, the extract of traditional Chinese medicine is usually a suspension with complex components, including solid particles, hydrocolloids, starch, protein, tannins, pigments, gums, inorganic salts and other complex components. From these Precipitation in the substance makes the clarity and stability of the Chinese medicine extract poor, which in turn affects the quality of the product Chinese medicine oral liquid preparation

The traditional impurity removal and clarification process is water extraction and alcohol precipitation method, but the precipitation of this method is not complete, and a large amount of precipitation will still occur after long-term storage, which will affect product quality